• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Behavior Research Methods, Instruments & Computers >Correlating brain metabolism with stereotypic and locomotor behavior
【24h】

Correlating brain metabolism with stereotypic and locomotor behavior

机译：将脑代谢与定型和运动行为相关

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many studies have shown that developmental cocaine exposure alters brain function and behavior; the present study examined the relationship between brain metabolism and behavioral responses to drug challenge. SKF 82958, a selective D1 dopamine agonist, was administered to preweaning cocaine-exposed (50 mg/kg/day) rats and controls at 60 days of age. Deoxyglucose was administered 30 min later, during the peak behavioral response, to measure brain functional activity. Pearson product-moment correlations of behavior (locomotor activity and stereotypic behavior) with rates of glucose metabolism in components of the nigrostriatal and mesolimbic circuits were analyzed. The analysis revealed that under saline-challenge conditions in control animals, rates of metabolism in mesolimbic regions are positively correlated to rates of locomotor activity, whereas in cocaine-treated rats, these correlations were absent. Following SKF challenge, a different pattern was seen; locomotor activity or stereotypic behavior was not correlated with mesolimbic or nigrostriatal metabolism, respectively, in controls but was positively correlated in cocaine-treated rats. Therefore, cocaine exposure during development enhances the coupling of metabolism in components of the mesolimbic and nigrostriatal dopamine systems with the behavioral output associated with these systems under drug-challenge conditions. This may be due to loss of inhibitory influences within the mesolimbic and nigrostriatal systems. Thus, the correlation of behavior and cerebral glucose metabolism provides a unique way of examining the effect of developmental cocaine exposure.
机译：许多研究表明，发育性可卡因暴露会改变大脑功能和行为。本研究检查了脑代谢与药物攻击行为反应之间的关系。在断奶前暴露于可卡因的大鼠（50 mg / kg /天）和对照组在60天龄时服用选择性D1多巴胺激动剂SKF 82958。 30分钟后，在行为反应高峰期间，给予脱氧葡萄糖以测量脑功能活动。分析了行为（自发活动和定型行为）与黑纹状体和中脑边缘回路中的葡萄糖代谢速率之间的皮尔逊乘积矩相关性。分析显示，在对照动物的生理盐水挑战条件下，中边缘边缘区的代谢率与运动能力呈正相关，而在可卡因治疗的大鼠中则没有这种相关性。在SKF挑战之后，看到了一种不同的模式。运动能力或刻板行为与对照组的中脑边缘或黑质纹状体代谢无关，但与可卡因治疗的大鼠呈正相关。因此，在开发过程中暴露于可卡因可增强中脑边缘和黑质纹状体多巴胺系统各组分之间的新陈代谢与在药物挑战条件下与这些系统相关的行为输出之间的耦合。这可能是由于中边缘和黑纹状体系统内抑制作用的丧失所致。因此，行为与脑葡萄糖代谢的相关性提供了一种检查发育性可卡因暴露影响的独特方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号