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首页> 外文期刊>Alexandria Journal of Medicine >The possible protective effect of lactoferrin on lipopolysaccharide-induced memory impairment in albino rats
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The possible protective effect of lactoferrin on lipopolysaccharide-induced memory impairment in albino rats

机译：乳铁蛋白对白化大鼠脂多糖诱导的记忆障碍的可能保护作用

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摘要

Generally, there are large number of people suffer from cognitive impairment, including impairment of learning, memory andattention.1 However, the exact mechanisms for cognitive dysfunction have remained unclear, oxidative stress and neuroinflammation may be in part, responsible for memory and learningimpairment.2 In particular, the elderly people are most susceptibleto cognitive impairment that may result from infection,3 in addition, the process of aging itself is associated with neuroinflammation involving production of proinflammtory cytokines andmicroglial activation.4 Also, neuroinflammation occurs in otherconditions that may lead to pathological changes in the brain aspostoperative dysfunction, ischemic stroke, Alzheimer disease(AD), multiple sclerosis or Parkinson disease.5 In some animalmodels, exposure to bacterial endotoxins, or viral coat proteins,will stimulate immune system resulting in memory and learningdeficits.
机译：通常，有很多人患有认知障碍，包括学习，记忆和注意力受损。1但是，认知功能障碍的确切机制仍不清楚，可能是氧化应激和神经炎症的部分原因，导致记忆和学习障碍。2特别是，老年人最容易受到感染引起的认知障碍的影响3，此外，衰老过程本身与神经炎症相关，涉及促炎性细胞因子的产生和小胶质细胞活化。4此外，神经炎症发生在其他情况下，可能导致病理术后脑功能异常，缺血性中风，阿尔茨海默病（AD），多发性硬化或帕金森氏病的改变。5在某些动物模型中，接触细菌内毒素或病毒外壳蛋白会刺激免疫系统，导致记忆力和学习障碍。

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