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The potential use of bromelain as a natural oral medicine having anticarcinogenic activities

机译：菠萝蛋白酶作为具有抗癌活性的天然口服药物的潜在用途

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Bromelain (BR), a protease extracted from Ananas comosus , reportedly possesses pharmacological activities including the reduction of thrombogenesis, and antihypertensive, and antimicrobial effects. This study aimed to investigate the potential effects of BR on oral cancer cells. The effect of BR on the viability of Ca9‐22 and SCC25 cells was determined using the MTT assay. These cells were also treated with different doses of BR, and Western blotting was conducted to monitor apoptosis. Finally, flow cytometry analysis was performed to identify sub‐G1 populations of oral cancer cells. After treatment, the viability of both Ca9‐22 and SCC25 cells was markedly reduced, in a dose‐dependent manner. BR induced poly (ADP‐ribose) polymerase (PARP) and lamin A/C degradation, and generated cleavage products. Flow cytometry analysis showed that BR treatment significantly increased the sub‐G1 population. Our findings therefore indicate that BR has potential as a novel, natural anticarcinogenic medicine.
机译：菠萝蛋白酶（BR）是一种从凤梨（Ananas comosus）提取的蛋白酶，据称具有药理活性，包括减少血栓形成，抗高血压和抗微生物作用。这项研究旨在研究BR对口腔癌细胞的潜在作用。使用MTT分析确定BR对Ca9-22和SCC25细胞活力的影响。还用不同剂量的BR处理这些细胞，并进行Western印迹以监测细胞凋亡。最后，进行流式细胞仪分析以鉴定口腔癌细胞的亚G1群体。治疗后，Ca9-22和SCC25细胞的活力均以剂量依赖性方式显着降低。 BR诱导了聚（ADP-核糖）聚合酶（PARP）和层状A / C降解，并产生了裂解产物。流式细胞仪分析表明，BR治疗显着增加了sub-G1人群。因此，我们的发现表明，BR具有作为新型天然抗癌药的潜力。

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