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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Mechanism of Klebsiella pneumoniae resistance to carbapenem antibiotics
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Mechanism of Klebsiella pneumoniae resistance to carbapenem antibiotics

机译：肺炎克雷伯菌对碳青霉烯类抗生素的耐药机制

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Purpose: To investigate the mechanism of action of Klebsiella pneumoniae (Kpn) resistance to carbapenem. Methods: The susceptibility of six Klebsiella pneumoniae strains to antibiotics was determined using K-B assay. Six isolated strains which were resistant to carbapenem were identified and collected using modified Hodge test. The phenotypes of metal enzyme were evaluated by ethylene diamine tetraacetic acid (EDTA) disk diffusion method. The genes for beta-lactamases, including KPC gene, were examined. Results: The six carbapenem-resistant strains of Klebsiella pneumoniae were resistant to imipenem, meropenem and aztreonam, but were sensitive to amikacin, fosfomycin, minocycline, and polymyxin. The six pathogens did not produce metal enzyme, but they produced carbapenemases. Moreover, the six strains partially carried blaTEM or blaSHV gene, but all had blaKPC-2 gene. Conclusion: These results suggest that the pathogens that contain blaKPC-2 gene may be involved in the mechanism of Klebsiella pneumoniae (Kpn) resistance to carbapenem.
机译：目的：探讨肺炎克雷伯菌（Kpn）对碳青霉烯类药物的抗性作用机理。方法：采用K-B法测定了6株肺炎克雷伯菌的耐药性。使用改良的Hodge试验鉴定并收集了六株对碳青霉烯有抗性的分离菌株。通过乙二胺四乙酸（EDTA）圆盘扩散法评价金属酶的表型。检查了β-内酰胺酶的基因，包括KPC基因。结果：6株肺炎克雷伯菌耐药菌株对亚胺培南，美罗培南和氨曲南具有耐药性，但对阿米卡星，磷霉素，米诺环素和多粘菌素敏感。六种病原体不产生金属酶，但产生碳青霉烯酶。此外，这6个菌株部分携带blaTEM或blaSHV基因，但都具有blaKPC-2基因。结论：这些结果表明，含有blaKPC-2基因的病原体可能与肺炎克雷伯菌对碳青霉烯的耐药性有关。

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