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Type 2 Innate Lymphoid Cells: Friends or Foes—Role in Airway Allergic Inflammation and Asthma

机译:2型先天淋巴样细胞:朋友还是敌人—在气道过敏性炎症和哮喘中的作用

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Innate-like lymphocytes (ILLs) and innate lymphoid cells (ILCs) are two newly characterized families of lymphocytes with limited and no rearranged antigen receptors, respectively. These soldiers provide a first line of defense against foreign insults by triggering a prompt innate immune response and bridging the gap of innate and adaptive immunity. Type 2 innate lymphoid cells (ILCs2) are newly identified members of the ILC family that play a key role in type 2 immune responses by prompt production of type 2 cytokines (especially IL-5 and IL-13) in response to antigen-induced IL-25/33 and by recruiting type 2 “immune franchise.” Regarding the two different roles of type 2 cytokines, helminth expulsion and type 2-related diseases, here we review the latest advances in ILC2 biology and examine the pivotal role of resident ILCs2 in allergen-specific airway inflammation and asthma.
机译:先天性淋巴细胞(ILLs)和先天性淋巴细胞(ILCs)是两个新近鉴定的淋巴细胞家族,分别具有有限的和没有重排的抗原受体。这些士兵通过触发及时的先天免疫反应并弥合先天免疫和适应性免疫的鸿沟,提供了抵御外来侮辱的第一道防线。 2型先天淋巴样细胞(ILCs2)是新近鉴定的ILC家族成员,通过响应抗原诱导的IL迅速产生2型细胞因子(特别是IL-5和IL-13),在2型免疫应答中起关键作用。 -25/33并通过招募2类“免疫专营权”。关于2型细胞因子,驱除蠕虫和2型相关疾病这两种不同的作用,在这里,我们回顾了ILC2生物学的最新进展,并研究了常驻ILCs2在过敏原特异性气道炎症和哮喘中的关键作用。

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