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首页> 外文期刊>Journal of Clinical Medicine Research >Birth Weight Independently Affects Morbidity and Mortality of Extremely Preterm Neonates
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Birth Weight Independently Affects Morbidity and Mortality of Extremely Preterm Neonates

机译：出生体重独立影响极早产儿的发病率和死亡率。

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Background: Neonates born between 24 + 0 and 27 + 6 gestational weeks, widely known as extremely preterm neonates, present a category characterized by increased neonatal mortality and morbidity. Main objective of the present study is to analyze the effect of various epidemiological and pregnancy-related parameters on unfavorable neonatal mortality and morbidity outcomes.Methods: A retrospective study was performed enrolling cases delivered during 2003 - 2008 in our department. Cases of neonatal death as well as pathological Apgar score (≤ 4 in the first and ≤ 7 in the fifth minute of life), need for emergency resuscitation, respiratory disease syndrome (RDS), neonatal asphyxia, intraventricular hemorrhage (IVH) and neonatal death were recorded for neonates of our analysis. A multivariate regression model was used to correlate these outcomes with gestational week at delivery, maternal age, parity, kind of gestation (singleton or multiple), intrauterine growth restriction (IUGR), birth weight (BW), preterm premature rupture of membranes (PPROM), mode of delivery (vaginal delivery or cesarean section) and antenatal use of corticosteroids.Results: Out of 5,070 pregnancies delivered, 57 extremely preterm neonates were born (1.1%). Mean BW was 780.35 ± 176.0, RDS was observed in 93.0% (n = 53), resuscitation was needed in 54.4% (n = 31) while overall mortality rate was 52.6% (n = 30). BW was independently associated with neonatal death (P = 0.004), pathological Apgar score in the first (P = 0.05) and fifth minute of life (P = 0.04) as well as neonatal sepsis (P = 0.05).Conclusion: BW at delivery is independently affecting neonatal mortality and morbidity parameters in extremely preterm neonates.J Clin Med Res. 2015;7(7):511-516doi: http://dx.doi.org/10.14740/jocmr2075w
机译：背景：胎龄在24 + 0至27 + 6孕周之间的婴儿，被广泛称为极端早产婴儿，其特征是新生儿死亡率和发病率增加。本研究的主要目的是分析各种流行病学和妊娠相关参数对不利的新生儿死亡率和发病率结果的影响。方法：采用回顾性研究方法，对2003-2008年在我科住院的病例进行登记。新生儿死亡以及病理学Apgar评分（生命中第一分钟≤4，第五分钟≤7），需要紧急复苏，呼吸系统疾病综合征（RDS），新生儿窒息，脑室内出血（IVH）和新生儿死亡的病例被记录为我们分析的新生儿。使用多元回归模型将这些结局与分娩时的孕周，产妇年龄，胎次，妊娠种类（单胎或多胎），宫内生长受限（IUGR），出生体重（BW），胎膜早破（PPROM）相关。 ），分娩方式（阴道分娩或剖宫产）和产前使用皮质类固醇激素。结果：在分娩的5,070例怀孕中，有57例极早产儿出生（1.1％）。平均体重为780.35±176.0，RDS率为93.0％（n = 53），需要复苏的为54.4％（n = 31），而总死亡率为52.6％（n = 30）。 BW与新生儿死亡（P = 0.004），出生后第一分钟（P = 0.05）和第五分钟的病理学Apgar评分（P = 0.04）以及新生儿败血症（P = 0.05）独立相关。对极早产儿的新生儿死亡率和发病率参数有独立影响。 2015; 7（7）：511-516doi：http://dx.doi.org/10.14740/jocmr2075w

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