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首页> 外文期刊>Journal of medical bacteriology. >Frequency of Quinolone Resistance and qnrB and qnrC Genes in Clinical Isolates of Klebsiella pneumoniae
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Frequency of Quinolone Resistance and qnrB and qnrC Genes in Clinical Isolates of Klebsiella pneumoniae

机译：肺炎克雷伯菌临床分离株对喹诺酮耐药的频率及qnrB和qnrC基因

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Background: Klebsiella pneumoniae is among the most common and significant agents of community and hospital-acquired infections. Plasmid mediated quinolone resistance (PMQR) was increasingly identified in Enterobacteriaceae family worldwide. Plasmid-mediated quinolone resistance (PMQR) was first reported in 1998 from a Klebsiella pneumoniae isolate in the USA. Till date, five Qnr proteins have been identified; QnrA, QnrB, QnrC, QnrD and QnrS. Quinolone are broad spectrum antibiotics the resistant to which has increasingly been reported among many bacterial species including Klebsiella. The aim of this study was the antibiotic resistance profile was determined based on resistance and molecular characterization of qnrB and qnrC genes in Klebsiella pneumoniae clinical isolated.Methods: In this cross sectional study, 94 samples of K. pneumoniae were collected. Isolates were screened for quinolone antibiotics resistance using disk diffusion method according to clinical and laboratory standards institute (CLSI) guidelines. Isolates with resistance to at least one of the quinolone antibiotics, examined for presence of the qnrB and qnrC genes.Results: Based on the obtained results by the Agar disk diffusion test, 29.78%, 27.65%, 28.72% and 27.65% of the isolates were resistant to nalidixic acid, ciprofloxacin, norfloxacin and ofloxacin, respectively. Of these 46.66% carried qnrB, 3.33% carried qnrC genes.?Conclusion: The identification of qnrB gene among quinolone-resistant K. pneumoniae isolates shows that the emergence of PMQR in this region requires serious preventive measures.
机译：背景：肺炎克雷伯菌是社区和医院获得性感染的最常见和最重要的病原体。质粒介导的喹诺酮耐药性（PMQR）在全世界肠杆菌科家族中越来越多地被发现。质粒介导的喹诺酮抗药性（PMQR）于1998年首次在美国的肺炎克雷伯菌分离株中报道。迄今为止，已鉴定出五种Qnr蛋白。 QnrA，QnrB，QnrC，QnrD和QnrS。喹诺酮是广谱抗生素，在包括克雷伯菌在内的许多细菌中，对它的耐药性日益增加。本研究的目的是根据临床分离的肺炎克雷伯菌qnrB和qnrC基因的耐药性和分子特征，确定抗生素耐药性。方法：本横断面研究收集了94例肺炎克雷伯菌样品。根据临床和实验室标准协会（CLSI）指南，使用圆盘扩散法筛选分离株的喹诺酮类抗生素耐药性。对至少一种喹诺酮类抗生素具有抗药性的菌株，检查其qnrB和qnrC基因的存在。结果：根据琼脂圆盘扩散试验获得的结果，分离株的29.78％，27.65％，28.72％和27.65％分别对萘啶酸，环丙沙星，诺氟沙星和氧氟沙星耐药。结论：在对喹诺酮耐药的肺炎克雷伯菌中分离到的qnrB基因表明，该区域PMQR的出现需要认真的预防措施。在这46.66％携带qnrB基因的人中，有3.33％携带qnrC基因。

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