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Evaluation of anxiolytic and novelty induced behaviours following bee-honey consumption in rats

机译:食用蜂蜜后大鼠抗焦虑和新奇行为的评价

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Bee honey has been shown to have many trace elements. Antibacterial and antioxidant properties of bee honey have been reported and employed for therapeutic purposes. The present work evaluates the anxiolytic values and effect on novelty induced behaviours of bee honey consumption. Wistar rats of either sex were given different concentrations of bee honey (10, 20 and 40%) at the dose of 0.5 ml/100 g p.o. The control rats were allowed access to distilled water?ad lib. Anxiolytic value was accessed in the Hole Board test while novelty induced behaviours were accessed in the Open-Field test. The result showed a significant dose dependent increase in exploratory activities of the experimental animals in the test groups when compared with the control (P<0.05) in the hole board test. In novelty induced behaviour tests, bee honey also produced a significant dose dependent increase in locomotor, rearing and grooming activities with the 40% concentration producing the highest level of significance when compared with the control (P<0.01). The results suggest that bee honey consumption mitigates anxiety and exerts excitatory effect on the central nervous system especially at the highest non-sedative dose.
机译:蜜蜂蜂蜜已被证明具有许多微量元素。蜜蜂蜂蜜的抗菌和抗氧化性能已被报道并用于治疗目的。本工作评估了蜜蜂蜂蜜消耗的抗焦虑作用及其对新奇行为的影响。雌雄同体的Wistar大鼠以0.5 ml / 100 g p.o的剂量服用不同浓度的蜂蜂蜜(10%,20%和40%)。允许对照大鼠自由地使用蒸馏水。在Hole Board测试中获得抗焦虑值,而在Open-Field测试中获得新颖性行为。结果表明,与孔板试验中的对照组相比,试验组中实验动物的探索活动具有显着的剂量依赖性增加(P <0.05)。在新颖性行为测试中,与对照相比,蜂蜂蜜在运动,饲养和修饰活动方面也产生了显着的剂量依赖性,其中40%的浓度具有最高的显着性水平(P <0.01)。结果表明,蜜蜂蜂蜜的摄入可以减轻焦虑,并对中枢神经系统产生兴奋作用,特别是在最高的非镇静剂量下。

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