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Mass spectrometry for the detection of potential psychiatric biomarkers

机译：质谱检测潜在的精神生物标志物

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摘要

The search for molecules that can act as potential biomarkers is increasing in the scientific community, including in the field of psychiatry. The field of proteomics is evolving and its indispensability for identifying biomarkers is clear. Among proteomic tools, mass spectrometry is the core technique for qualitative and quantitative identification of protein markers. While significant progress has been made in the understanding of biomarkers for neurodegenerative diseases such as Alzheimer’s disease, multiple sclerosis and Parkinson’s disease, psychiatric disorders have not been as extensively investigated. Recent and successful applications of mass spectrometry-based proteomics in fields such as cardiovascular disease, cancer, infectious diseases and neurodegenerative disorders suggest a similar path for psychiatric disorders. In this brief review, we describe mass spectrometry and its use in psychiatric biomarker research and highlight some of the possible challenges of undertaking this type of work. Further, specific examples of candidate biomarkers are highlighted. A short comparison of proteomic with genomic methods for biomarker discovery research is presented. In summary, mass spectrometry-based techniques may greatly facilitate ongoing efforts to understand molecular mechanisms of psychiatric disorders.
机译：在包括精神病学领域在内的科学界，对可以用作潜在生物标志物的分子的搜索正在增加。蛋白质组学领域正在发展，其在识别生物标志物方面的必不可少。在蛋白质组学工具中，质谱法是定性和定量鉴定蛋白质标记物的核心技术。尽管在了解神经退行性疾病（例如阿尔茨海默氏病，多发性硬化症和帕金森氏病）的生物标志物方面已取得了重大进展，但对精神病的研究尚未得到广泛的研究。基于质谱的蛋白质组学在心血管疾病，癌症，传染病和神经退行性疾病等领域的最新成功应用表明，精神疾病的治疗途径相似。在这篇简短的评论中，我们描述了质谱及其在精神病学生物标志物研究中的用途，并着重指出了进行此类工作的一些可能挑战。此外，突出显示了候选生物标志物的具体实例。蛋白质组学与基因组方法进行生物标记物发现研究的简短比较。总之，基于质谱的技术可以极大地促进正在进行的努力，以了解精神疾病的分子机制。

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