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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay in plants
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RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay in plants

机译：RNS2是RNase T2家族的保守成员，对于植物中核糖体RNA的降解是必需的

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摘要

RNase T2 enzymes are conserved in most eukaryotic genomes, and expression patterns and phylogenetic analyses suggest that they may carry out an important housekeeping role. However, the nature of this role has been elusive. Here we show that RNS2, an intracellular RNase T2 from Arabidopsis thaliana, is essential for normal ribosomal RNA recycling. This enzyme is the main endo-ribonuclease activity in plant cells and localizes to the endoplasmic reticulum (ER), ER-derived structures, and vacuoles. Mutants lacking RNS2 activity accumulate RNA intracellularly, and rRNA in these mutants has a longer half-life. Normal rRNA turnover seems essential to maintain cell homeostasis because ms2 mutants display constitutive autophagy. We propose that RNS2 is part of a process that degrades rRNA to recycle its components. This process appears to be conserved in all eukaryotes.
机译：RNase T2酶在大多数真核基因组中都是保守的，表达模式和系统发育分析表明它们可能发挥重要的管家作用。但是，此角色的性质难以捉摸。在这里，我们显示RNS2，一种来自拟南芥的细胞内RNase T2，对于正常的核糖体RNA回收至关重要。该酶是植物细胞中的主要核糖核酸内切酶活性，位于内质网（ER），ER衍生的结构和液泡中。缺乏RNS2活性的突变体会在细胞内积累RNA，而这些突变体中的rRNA的半衰期更长。正常的rRNA转换似乎对于维持细胞稳态至关重要，因为ms2突变体显示出组成型自噬。我们建议RNS2是降解rRNA以回收其成分的过程的一部分。这个过程似乎在所有真核生物中都是保守的。

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    Melissa S. Hillwig; Anthony L. Contento; Alexander Meyer; Danielle Ebany; Diane C. Bassham; Gustavo C. Macintosh;

  • 作者单位

    Department of Biochemistry, Biophysics and Molecular Biology,Iowa State University, Ames, IA 50011;

    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011;

    Department of Biochemistry, Biophysics and Molecular Biology,Iowa State University, Ames, IA 50011;

    Department of Biochemistry, Biophysics and Molecular Biology,Iowa State University, Ames, IA 50011;

    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011;

    Department of Biochemistry, Biophysics and Molecular Biology,Iowa State University, Ames, IA 50011;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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