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首页> 外文期刊>The European Journal of Neuroscience >Migration of LHRH neurons into the spinal cord: evidence for axon-dependent migration from the transplanted chick olfactory placode.
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Migration of LHRH neurons into the spinal cord: evidence for axon-dependent migration from the transplanted chick olfactory placode.

机译：LHRH神经元向脊髓的迁移：从移植的鸡嗅斑中轴突依赖性迁移的证据。

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摘要

In the chick embryo, luteinizing hormone-releasing hormone (LHRH) neurons originate in the olfactory placode and migrate along the olfactory nerve to the forebrain. In previous studies, we demonstrated that LHRH neurons followed the trigeminal nerve when the olfactory nerve was physically interrupted. To examine whether LHRH neurons possess the capacity to migrate along the different type of axons, the olfactory placode was transplanted into the base of the forelimb. Three to five days after the transplantation, LHRH neurons were detectable in the spinal nerve, the dorsal root ganglion, the sympathetic ganglion and the spinal cord. Double or triple labelling studies for LHRH, somatostatin and/or axonin-1 showed that LHRH neurons entered the spinal nerve in contact with the olfactory axons, which are specifically immunoreactive to somatostatin. Migrating LHRH neurons continued to associate closely with the olfactory axons in the spinal nerve. However, some LHRH neurons often migrated along with the axonin-1 positive spinal sensory axons, maintaining a distance from the olfactory axons. Furthermore, a few LHRH neurons were observed in the ventral root and the ventral funiculus independent of olfactory axons. As LHRH neurons were observed in the motor component of the spinal nerve, it is probable that LHRH neurons also invaded the spinal cord using the motor axons as a guiding substrate for their migration. These results suggest that the migration mode of LHRH neurons is axon dependent in the peripheral region, however, chemical identity with regard to axonal substrate choice for migration was not specified in the present study.
机译：在雏鸡胚胎中，促黄体生成激素释放激素（LHRH）神经元起源于嗅觉斑块，并沿嗅觉神经迁移至前脑。在以前的研究中，我们证明了嗅觉神经受到物理干扰时，LHRH神经元会跟随三叉神经。为了检查LHRH神经元是否具有沿着不同类型轴突迁移的能力，将嗅觉斑块移植到前肢的底部。移植后三到五天，在脊髓神经，背根神经节，交感神经节和脊髓中可检测到LHRH神经元。对LHRH，生长抑素和/或轴突蛋白1的双重或三重标记研究表明，LHRH神经元与嗅觉轴突接触进入脊髓神经，嗅觉轴突对生长抑素具有特异性免疫反应。迁移的LHRH神经元继续与脊髓神经中的嗅轴突紧密联系。但是，一些LHRH神经元通常与轴突1阳性脊髓感觉轴突一起迁移，与嗅觉轴突保持一定距离。此外，在腹侧根和腹侧支叶中观察到一些LHRH神经元，独立于嗅轴突。因为在脊髓神经的运动成分中观察到LHRH神经元，所以很可能LHRH神经元也以运动轴突作为其迁移的引导底物侵入了脊髓。这些结果表明，LHRH神经元在周围区域的迁移模式是轴突依赖性的，但是，在本研究中未指定关于迁移的轴突底物选择的化学同一性。

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