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首页> 外文期刊>The Journal of Antibiotics: An International Journal >In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii.
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In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii.

机译：替加环素和粘菌素对鲍德不动杆菌的体外协同活性。

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摘要

The emergence of extensive drug-resistant (XDR) Acinetobacter baumannii limits the therapeutic options and leads to high mortality in intensive care units. Combined antibiotic therapy is frequently recommended for the treatment of these infections. Colistin (CO) and tigecycline (TIG), alone or in combination with other antimicrobials, are the most commonly used antibiotics in the treatment of these resistant infections. In this study, the in vitro synergistic activity of TIG and CO were tested for 25 XDR-A. baumannii strains isolated from ventilator-associated pneumonia by the Etest method. Resistance to CO was not detected, whereas 8% of the strains were resistant to TIG. The TIG-CO combination was more synergistic than TIG-rifampin and CO-rifampin according to the fractional inhibitory concentration index. No antagonism was detected between the drugs in the study. There was no strong correlation between the activity of the combinations with reference to strains or genotypes. Our results suggest that the combined use of TIG and CO may be useful for the treatment of XDR-A. baumannii infections.
机译：广泛的耐药性（XDR）鲍曼不动杆菌的出现限制了治疗选择，并导致重症监护病房的高死亡率。经常推荐联合抗生素治疗这些感染。 Colistin（CO）和tigecycline（TIG）单独或与其他抗微生物药物联合使用，是治疗这些耐药性感染最常用的抗生素。在这项研究中，TIG和CO在25 XDR-A的体外协同活性进行了测试。通过Etest方法从呼吸机相关性肺炎中分离出鲍曼氏菌株。未检测到对CO的抗性，而8％的菌株对TIG具有抗性。根据分数抑制浓度指数，TIG-CO组合比TIG-rifampin和CO-rifampin更协同。在研究中的药物之间未检测到拮抗作用。组合的活性与菌株或基因型之间没有强烈的相关性。我们的结果表明，TIG和CO的联合使用可能对XDR-A的治疗有用。鲍曼氏菌感染。

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