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首页> 外文期刊>The Journal of Antimicrobial Chemotherapy >Plasmid-mediated quinolone resistance due to qnrB5 and qnrS1 genes in Salmonella enterica serovars Newport, Hadar and Saintpaul isolated from turkey meat in Denmark.
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Plasmid-mediated quinolone resistance due to qnrB5 and qnrS1 genes in Salmonella enterica serovars Newport, Hadar and Saintpaul isolated from turkey meat in Denmark.

机译：质粒介导的喹诺酮耐药性是由于从丹麦火鸡肉中分离出的沙门氏菌沙门氏菌纽波特，哈达尔和圣保罗中的qnrB5和qnrS1基因引起的。

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摘要

Recently, new transferable mechanisms conferring low-level quinolone resistance have been described. The first gene found was qnrA, followed by other qnr genes (B and S), and a large number of variants of these genes have been found to date.1 qnr genes encode proteins that protect topoisomerases and reduce susceptibility to fluoroquinolones. At first, these genes were found very rarely, but now they seem to have spread more rapidly than expected and have been found in the USA, Africa, Asia and also in Europe. Furthermore, other genes encoding transferable quinolone resistance have been described: aac(6')Ib-cr encodes an aminoglycoside-modifying enzyme able to modify ciprofloxacin.
机译：最近，已经描述了赋予低水平喹诺酮抗性的新的可转移机制。发现的第一个基因是qnrA，其次是其他qnr基因（B和S），迄今为止，已经发现了这些基因的许多变异体。1qnr基因编码的蛋白可以保护拓扑异构酶并降低对氟喹诺酮类药物的敏感性。最初，这些基因很少被发现，但是现在它们似乎以比预期更快的速度传播，并在美国，非洲，亚洲以及欧洲被发现。此外，已经描述了编码可转移的喹诺酮抗性的其他基因：aac（6'）Ib-cr编码能够修饰环丙沙星的氨基糖苷修饰酶。

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