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首页> 外文期刊>The journal of clinical psychiatry >Polypharmacy in patients with schizophrenia.
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Polypharmacy in patients with schizophrenia.

机译：精神分裂症患者的多药治疗。

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BACKGROUND: Polypharmacy in patients with schizophrenia is a common practice with little basis in well-controlled studies. The objective of this report is to describe the changes in prescription practices with psychotropic medications for patients diagnosed with schizophrenia in 1995 and 2000. METHOD: The medical records of patients who were discharged from our facility in 1995 and 2000 with the diagnosis of schizophrenia (DSM-IV criteria) were reviewed. The psychotropic medications at discharge were compared. The incidence of adverse drug reactions and indicators of patient outcome were also compared. RESULTS: 459 records were reviewed for 1995 and 584 were reviewed for 2000. Patients discharged in 2000 were significantly more likely to receive antidepressants, mood stabilizers, anxiolytics, and multiple antipsychotics than patients discharged in 1995 (p < .0001). Patients discharged in 2000 were given significantly fewer anticholinergics (p < .0001). There was a large increase in the use of divalproex. No patients were discharged on treatment with more than 1 antipsychotic in 1995, whereas in 2000, 15.9% of patients were. The most common antipsychotic combination was haloperidol and olanzapine. Paralleling the increased use of polypharmacy, there were significantly fewer adverse drug reactions in 2000 than in 1995 (p = .002). In addition, patients with schizophrenia who were discharged in 2000 had significantly shorter lengths of stay (p < .0001) and were significantly more likely to be discharged to the community than to a state hospital (p = .0001). CONCLUSION: This study found that acutely ill hospitalized patients with schizophrenia are being treated with more psychotropic medications, including more than 1 antipsychotic. These changes are coincidental with a decrease in adverse drug reactions and an improvement in indicators of patient outcome.
机译：背景：精神分裂症患者的多药房治疗是一种普遍的实践，在良好对照的研究中缺乏基础。本报告的目的是描述1995年和2000年诊断为精神分裂症的患者使用精神药物的处方做法的变化。方法：1995年和2000年因诊断为精神分裂症（DSM）而从我们设施出院的患者的病历-IV标准）进行了审查。比较出院时的精神药物。还比较了药物不良反应的发生率和患者预后的指标。结果：1995年审查了459条记录，2000年审查了584条记录。与1995年出院的患者相比，2000年出院的患者接受抗抑郁药，情绪稳定剂，抗焦虑药和多种抗精神病药的可能性要高得多（p <.0001）。 2000年出院的患者服用的抗胆碱药明显减少（p <.0001）。 divalproex的使用量大大增加。 1995年，没有患者接受超过1种抗精神病药的治疗，而2000年，这一比例为15.9％。最常见的抗精神病药物组合是氟哌啶醇和奥氮平。与多药店使用增加平行的是，与1995年相比，2000年的药品不良反应显着更少（p = .002）。此外，2000年出院的精神分裂症患者的住院时间明显缩短（p <.0001），出院的可能性大大高于国立医院（p = .0001）。结论：这项研究发现，正在住院的精神分裂症急性病患者正在接受更多的精神药物治疗，包括多于一种抗精神病药物。这些变化与药物不良反应的减少和患者预后指标的改善同时发生。

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