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首页> 外文期刊>The Korean Journal of Parasitology >Trichinella spiralis Infection Suppressed Gut Inflammation with CD4(+)CD25(+)Foxp3(+) T Cell Recruitment
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Trichinella spiralis Infection Suppressed Gut Inflammation with CD4(+)CD25(+)Foxp3(+) T Cell Recruitment

机译：旋毛虫感染抑制了CD4（+）CD25（+）Foxp3（+）T细胞募集的肠道炎症

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In order to know the effect of pre-existing Trichinella spiralis infection on experimentally induced intestinal inflammation and immune responses, we induced colitis in T. spiralis-infected mice and observed the severity of colitis and the levels of Th1, Th2, and regulatory cytokines and recruitment of CD4+CD25+Foxp3+ T (regulatory T; Treg) cells. Female C57BL/6 mice were infected with 250 muscle larvae; after 4 weeks, induction of experimental colitis was performed using 3% dextran sulfate sodium (DSS). During the induction period, we observed severity of colitis, including weight loss and status of stool, and evaluated the disease activity index (DAI). A significantly low DAI and degree of weight loss were observed in infected mice, compared with uninfected mice. In addition, colon length in infected mice was not contracted, compared with uninfected mice. We also observed a significant increase in production of pro-inflammatory cytokines, IL-6 and IFN-γ, in spleen lymphocytes treated with DSS; however, such an increase was not observed in infected mice treated with DSS. Of particular interest, production of regulatory cytokines, IL-10 and transforming growth factor (TGF)-β, in spleen lymphocytes showed a significant increase in mice infected with T. spiralis. A similar result was observed in mesenteric lymph nodes (MLN). Subsets of the population of Treg cells in MLN and spleen showed significant increases in mice infected with T. spiralis. In conclusion, T. spiralis infection can inhibit the DSS-induced colitis in mice by enhancing the regulatory cytokine and Treg cells recruitment.
机译：为了了解先前存在的旋毛虫旋毛虫感染对实验诱导的肠道炎症和免疫反应的影响，我们在感染了旋毛虫的小鼠中诱发了结肠炎，并观察了结肠炎的严重程度以及Th1，Th2和调节性细胞因子的水平。 CD4 + CD25 + Foxp3 + T（调节性T; Treg）细胞的募集。雌性C57BL / 6小鼠感染了250只肌肉幼虫。 4周后，使用3％葡聚糖硫酸钠（DSS）进行实验性结肠炎的诱导。在诱导期间，我们观察了结肠炎的严重程度，包括体重减轻和粪便状态，并评估了疾病活动指数（DAI）。与未感染的小鼠相比，在感染的小鼠中观察到明显较低的DAI和体重减轻程度。另外，与未感染的小鼠相比，被感染的小鼠的结肠长度没有收缩。我们还观察到用DSS处理的脾淋巴细胞中促炎性细胞因子IL-6和IFN-γ的产生显着增加。然而，在用DSS治疗的感染小鼠中未观察到这种增加。特别令人感兴趣的是，脾淋巴细胞中调节性细胞因子，IL-10和转化生长因子（TGF）-β的产生表明，感染螺旋螺旋体的小鼠显着增加。在肠系膜淋巴结（MLN）中观察到类似结果。 MLN和脾脏中Treg细胞群体的子集显示，感染螺旋螺旋体的小鼠显着增加。总之，螺旋螺旋体感染可通过增强调节性细胞因子和Treg细胞募集而抑制DSS诱导的小鼠结肠炎。

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