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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Single and combined effects of cerebral white matter lesions and lacunar infarctions on cognitive function in an elderly population.
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Single and combined effects of cerebral white matter lesions and lacunar infarctions on cognitive function in an elderly population.

机译：脑白质病变和腔隙性梗塞对老年人群认知功能的单一和综合影响。

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BACKGROUND: This study is to investigate the association between single and combined vascular brain changes (white matter lesions [WMLs], lacunar infarctions) and the cognitive domains of memory, processing speed, and motor function in the elderly adults. METHODS: In a sample of 268 participants aged 65-83 years of the MEMO (Memory and Morbidity in Augsburg Elderly) population-based study in Augsburg, Germany, cerebral magnetic resonance imaging (MRI) was performed and a detailed neuropsychological test battery applied. Analysis of covariance determined the effects of vascular brain changes on domains of cognitive functioning. RESULTS: Strong associations of large WMLs and of MRI-defined lacunar infarction with three different domains of cognitive function even after adjustment for age, gender, and education were found. The combined occurrence of both lesions affected about one in 10 participants and was associated with a strong decrease in cognitive function in all domains. The difference between the groups with only one lesion type (either large WMLs or MRI-defined infarction) and participants affected by both was significant in the domains of processing speed and memory, even after adjustment for important confounders such as age, gender, education, and comorbidities. The effects of both lesion types on cognitive function were not more than additive. CONCLUSIONS: Our study shows that both large WMLs and MRI-defined lacunar infarction contribute to impairments in different cognitive domains. The results suggest that their combined occurrence is associated with stronger reductions in cognitive function than each of the two brain lesion types alone.
机译：背景：本研究旨在探讨老年人的单次和合并血管性脑部变化（白质损伤[WML]，腔隙性脑梗塞）与记忆，加工速度和运动功能的认知范围之间的关系。方法：在德国奥格斯堡的268位年龄在65-83岁的MEMO（奥格斯堡老年人的记忆和发病率）人群研究中，进行了脑磁共振成像（MRI），并应用了详细的神经心理学测试电池。协方差分析确定了血管性大脑变化对认知功能范围的影响。结果：即使调整了年龄，性别和教育程度，也发现大型WML和MRI定义的腔隙性脑梗死与认知功能的三个不同领域之间密切相关。两种病变的合并发生影响了十分之一的参与者，并且与所有领域的认知功能大大降低有关。即使调整了年龄，性别，学历等重要混杂因素，只有一种病变类型的组（较大的WML或MRI定义的梗塞）与受这两种病变影响的参与者之间的差异在处理速度和记忆力方面也很明显。和合并症。两种病变类型对认知功能的影响不超过累加性。结论：我们的研究表明，大的WML和MRI定义的腔隙性脑梗塞均会导致不同认知领域的损伤。结果表明，与单独的两种脑病变类型相比，它们的联合发生与更强的认知功能降低相关。

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