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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease.
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Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease.

机译：氧化的低密度脂蛋白受体-1基因的多态性和阿尔茨海默氏病的风险。

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摘要

The +1073 C/T polymorphism of the oxidized low-density lipoprotein receptor-1 (OLR1) gene has been reported to be associated with late-onset Alzheimer's disease, whereas for the +1071 T/A polymorphism no association was found. We genotyped 169 sporadic Alzheimer's disease patients and 264 sex- and age-matched nondemented controls from Southern Italy for OLR1 +1073 C/T and +1071 T/A polymorphisms and for apolipoprotein E and LBP-1c/CP2/LSF. We also performed haplotype analysis. For the +1073 C/T polymorphism, the C allele and the CC genotype have been associated with a higher risk for Alzheimer's disease without apolipoprotein E or CP2 interaction. The two polymorphisms were in linkage disequilibrium, with the haplotype T-C at significant increased risk of developing Alzheimer's disease in the whole sample and in elderly persons 70 years or older. In our population, the +1073 C/T OLR1 polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of OLR1 as a candidate risk gene for sporadic Alzheimer's disease.
机译：据报道，氧化的低密度脂蛋白受体-1（OLR1）基因的+1073 C / T多态性与迟发性阿尔茨海默氏病有关，而对于+1071 T / A多态性则没有发现。我们对来自意大利南部的169例散发性阿尔茨海默氏病患者和264位性别和年龄匹配的非痴呆对照进行了基因分型，分析了OLR1 +1073 C / T和+1071 T / A多态性以及载脂蛋白E和LBP-1c / CP2 / LSF。我们还进行了单倍型分析。对于+1073 C / T多态性，C基因等位基因和CC基因型与无载脂蛋白E或CP2相互作用的阿尔茨海默氏病风险较高相关。这两个多态性在连锁不平衡中，单体型T-C在整个样本中以及70岁或以上的老年人中患阿尔茨海默氏病的风险显着增加。在我们的人群中，+ 1073 C / T OLR1多态性表现出与阿尔茨海默氏病的显着相关性，进一步支持了OLR1作为散发性阿尔茨海默氏病的候选风险基因的作用。

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