Synthesis of dicarboxylic acylcarnitines

Johnson DW

首页> 外文期刊>Chemistry and Physics of Lipids >Synthesis of dicarboxylic acylcarnitines

【24h】

Synthesis of dicarboxylic acylcarnitines

机译：二羧酸酰基肉碱的合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Syntheses of malonyl, rnethylmalonyl, succinyl, glutaryl, methylglutaryl, dodecanedioyl and hexadecanedioyl carnitines are described. The dicarboxylic acylcarnitines were prepared from eight equivalents of cyclic anhydride or isopropylidene ester of the dicarboxylic acid and carnitine chloride in trifluoroacetic acid solution. Long chain dicarboxylic acylcarnitines were additionally purified by partitioning between water and n-butanol. Stable isotope labeled analogs, containing 3, 6 or 9 deuterium atoms. were also prepared. They are for use as standards in the electrospray ionization tandem mass spectrometric analysis of dicarboxylic acylcarnitines in samples from patients with inherited disorders of fatty acid oxidation. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

机译：描述了丙二酰基，丙二酰基丙二酰基，琥珀酰基，戊二酰基，甲基戊二酰基，十二烷二酰基和十六烷二酰基肉碱的合成。由在三氟乙酸溶液中的八当量的二羧酸的环状酸酐或异亚丙基酯和肉碱氯化物制备二羧酸酰基肉碱。长链二羧酸酰基肉碱还通过在水和正丁醇之间分配进行纯化。稳定同位素标记的类似物，包含3、6或9个氘原子。也准备好了。它们用作电喷雾电离串联质谱分析中患有脂肪酸氧化遗传性疾病的患者样品中二羧酸酰基肉碱的标准。（C）2004 Elsevier Ireland Ltd.保留所有权利。

著录项

来源
《Chemistry and Physics of Lipids》 |2004年第2期|共11页
作者
Johnson DW;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
dicarboxylic acid; acylcarnitine; glutarylcarnitine; deuterium labeling; tandem mass spectrometry; newborn screening; TANDEM MASS-SPECTROMETRY; DEFICIENCY; DIAGNOSIS; CARNITINE; ACIDURIA;

机译：二羧酸;酰基肉碱;戊二酰肉碱;氘标记;串联质谱;新生儿筛查;串联质谱;缺陷;诊断;肉碱;酸;

相似文献

外文文献
中文文献
专利

1. Simultaneous quantification of acylcarnitine isomers containing dicarboxylic acylcarnitines in human serum and urine by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry [J] . Maeda Y, Ito T, Suzuki A, Rapid Communications in Mass Spectrometry: RCM . 2007,第5期

机译：高效液相色谱/电喷雾串联质谱法同时定量测定人血清和尿液中含二羧酸酰基肉碱的酰基肉碱异构体
2. Kinetic and molecular orbital analyses of dicarboxylic acylcarnitine methylesterification show that derivatization may affect the screening of newborns by tandem mass spectrometry [J] . Maeda Yasuhiro, Nakajima Yoko, Gotoh Kana, Bioorganic and Medicinal Chemistry Letters . 2016,第1期

机译：二羧酸酰基肉碱甲基酯化的动力学和分子轨道分析表明，衍生化可能会影响串联质谱法对新生儿的筛选
3. Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids [J] . Fiamoncini Jarlei, Lima Thais M., Hirabara Sandro M., Molecular Nutrition and Food Research . 2015,第8期

机译：中链二羧酸酰基肉碱作为n-3 PUFA诱导的脂肪酸过氧化物酶氧化的标志物
4. Evaluation of Acylcarnitines with Dicarboxylic Acid Residues as Candidate Markers for Neurodegenerative Syndromes [C] . Andrea Raffaelli, Riccardo Donzelli, Alessandro Saba, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：用二羧酸残基评价酰基羧酸氨基作为神经变性综合征的候选标志物
5. Part one. Synthesis of phosphorus-containing amino acid analogues derived from trans-4-hydroxyproline and the study of their bioactivity in the glutamate excitatory neurotransmitter system. Part two. Synthesis, structural modifications and in vitro pharmacology of quinoline-2,4-dicarboxylic acids as proposed inhibitors of the glutamate vesicular transporter. [D] . Carrigan, Christina Nicole. 2000

机译：第一部分。反式-4-羟基脯氨酸衍生的含磷氨基酸类似物的合成及其在谷氨酸兴奋性神经递质系统中的生物活性的研究。第二部分。喹啉-2,4-二羧酸作为谷氨酸囊泡转运蛋白的抑制剂的合成，结构修饰和体外药理作用。
6. Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and β-oxidation [O] . Vito Iacobazzi, Vittoria Infantino, Ferdinando Palmieri 2013

机译：线粒体柠檬酸和肉碱/酰基肉碱转运蛋白的转录调控：两个基因参与脂肪酸的生物合成和β氧化。
7. Synthesis of 3, 2prime;, 6prime;-Trimethoxy-diphenyl Ether-5, 4prime;-dicarboxylic Acid and 2, 3, 2prime;, 6prime;-Tetramethoxy-diphenyl Ether-5, 4prime;-dicarboxylic Acid [O] . Yasuo Inubushi, Tameyuki Amano 1952

机译：合成3,2'，6'-三甲氧基 - 二苯基醚-5,4'-二羧酸和2,3,2'，6'-四甲氧基 - 二苯基醚-5,4'-二羧酸
8. Biosynthesis of long-chain dicarboxylic acid monomers from renewable resources.211 Final technical report [R] . Mobley, D. P. 1999

机译：来自可再生资源的长链二羧酸单体的生物合成.211最终技术报告

Synthesis of dicarboxylic acylcarnitines

摘要

著录项

相似文献

相关主题

期刊订阅