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首页> 外文期刊>Zoological Science >Identification and Distribution of Three Gonadotropin-Releasing Hormone (GnRH) Isoforms in the Brain of a Clupeiform Fish, Engraulis japonicus
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Identification and Distribution of Three Gonadotropin-Releasing Hormone (GnRH) Isoforms in the Brain of a Clupeiform Fish, Engraulis japonicus

机译：up形鱼Fish脑中三种促性腺激素释放激素（GnRH）亚型的鉴定和分布

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摘要

To gain a better understanding of the reproductive endocrinology of a primitive order clupeiform fish (Japanese anchovy, Engraulis japonicus), cDNAs encoding three gonadotropin-releasing hormone (GnRH) isoforms were isolated from the brain, and their distribution was analyzed using in-situ hybridization (ISH). The three GnRH isoforms include GnRH1 (herring GnRH), GnRH2 (chicken GnRH-II) and GnRH3 (salmon GnRH), and their full-length cDNAs encode 88, 86, and 89 deduced amino acids (aa), respectively. Alignment analysis of Japanese anchovy GnRH isoforms showed lower identities with other teleost fish. The major population of GnRH1 neurons was localized in the ventral telencephalon (VT) and nucleus preopticus (NPO) of the preoptic area (POA) with minor population in the anterior olfactory bulb (OB). GnRH2 neurons were restricted to the midbrain tegmentum (MT), specific to the nucleus of the medial longitudinal fasciculus (nMLF). GnRH3 neurons were localized in the olfactory nerve (ON), ventral OB, and transitional area between OB and ON. Interestingly, GnRH1 neurons were also localized in the olfactory bulb, in addition to its major population in the preoptic area. These results indicate the differential distribution of three GnRH isoforms expressed in the brain of the Japanese anchovy.
机译：为了更好地了解原始有序鳞茎类鱼类（日本an鱼，日本gra鱼）的生殖内分泌学，从大脑中分离出编码三种促性腺激素释放激素（GnRH）同工型的cDNA，并使用原位杂交对其分布进行了分析。 （ISH）。这三种GnRH亚型包括GnRH1（鲱鱼GnRH），GnRH2（鸡GnRH-II）和GnRH3（鲑鱼GnRH），它们的全长cDNA分别编码88、86和89个推导的氨基酸（aa）。日本an鱼GnRH亚型的比对分析显示与其他硬骨鱼的同一性较低。 GnRH1神经元的主要种群定位在视前区的腹侧端脑（VT）和视前核（NPO）中，前嗅球（OB）中的种群较少。 GnRH2神经元仅限于中脑腱膜（MT），特定于内侧纵筋膜（nMLF）的核。 GnRH3神经元位于嗅神经（ON），腹侧OB和OB与ON之间的过渡区域。有趣的是，GnRH1神经元除了位于视前区以外，还位于嗅球中。这些结果表明日本凤尾鱼的大脑中表达的三种GnRH亚型的差异分布。

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