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首页> 外文期刊>Journal of Applied Polymer Science >SYNTHESIS AND BIOLOGICAL ACTIVITIES OF ENDO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIMIDE AND ITS POLYMERS
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SYNTHESIS AND BIOLOGICAL ACTIVITIES OF ENDO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIMIDE AND ITS POLYMERS

机译：ENDO-3,6-环氧-1,2,3,6-四氢邻苯二甲酰亚胺及其聚合物的合成及生物活性

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Photocopolymerizations of endo-3,6-epoxy-1,2,3,6-tetrahydrophthalimide (ETPI) with acrylic acid (AA), vinyl acetate (VAc), and maleic anhydride (MAH) were carried out in a mixed solvent of 2-butanone and acetone using 2,2-dimethoxy-2-phenylacetophenone as an initiator at 25 degrees C. Synthesized ETPI, poly(ETPI), poly(ETPI-co-AA), poly(ETPI-co-VAc), and poly(ETPI-co-MAH) were characterized by IR and H-1-NMR spectroscopies, elemental analysis, and gel permeation chromatography. The synthesized polymers have a number-average molecular weight ((M) over bar(n)) in the range of 3500-27,400. The in vitro cytotoxicities of poly(ETPI), poly(ETPI-co-AA), poly(ETPI-co-VAc), and poly(ETPI-co-MAH) against fibroblast and K-562 human leukemia cells were lower than that of monomeric ETPI at a low concentration (0.02 mg/mL). The in vivo antitumor activities of the polymers were evaluated by the survival time with sarcoma 180 tumor-bearing mice. The polymers showed higher antitumor activity and lower toxicity than both monomeric ETPI and 5-fluorouracil at all doses tested. (C) 1997 John Wiley & Sons, Inc. [References: 16]
机译：在3的混合溶剂中进行内3,6-环氧-1,2,3,6-四氢邻苯二甲酰亚胺（ETPI）与丙烯酸（AA），乙酸乙烯酯（VAc）和马来酸酐（MAH）的光共聚合。 -2,2-二甲氧基-2-苯基苯乙酮作为引发剂在25°C下合成丁酮和丙酮。合成了ETPI，poly（ETPI），poly（ETPI-co-AA），poly（ETPI-co-VAc）和poly （ETPI-co-MAH）通过IR和H-1-NMR光谱，元素分析和凝胶渗透色谱进行表征。合成的聚合物具有在3500-27,400范围内的数均分子量（（M）超过bar（n））。聚（ETPI），聚（ETPI-co-AA），聚（ETPI-co-VAc）和聚（ETPI-co-MAH）对成纤维细胞和K-562人白血病细胞的体外细胞毒性低于低浓度（0.02 mg / mL）的单体ETPI。聚合物的体内抗肿瘤活性通过肉瘤180瘤小鼠的存活时间来评估。在所有测试剂量下，该聚合物均比单体ETPI和5-氟尿嘧啶显示出更高的抗肿瘤活性和更低的毒性。 （C）1997 John Wiley＆Sons，Inc. [参考：16]

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