...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Prophylaxis against organophosphate poisoning by sustained release of scopolamine and physostigmine.
【24h】

Prophylaxis against organophosphate poisoning by sustained release of scopolamine and physostigmine.

机译：通过东pol碱和毒扁豆碱的持续释放预防有机磷酸盐中毒。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Protection efficacy of continuous prophylactic administration of physostigmine and scopolamine against sarin-induced toxicity was evaluated previously in guinea pigs. The present study in large animals used Beagle dogs, that serve as an animal model with cholinergic sensitivity similar to that of humans. Pretreatment with physostigmine salicylate and scopolamine hydrochloride at dose rates of 2.5 and 1 microg x kg(-1) x h(-1), respectively, was administered via Alzet mini-osmotic pumps. At the time of exposure, the physostigmine salicylate concentration in plasma was 0.7 ng x ml(-1) and the scopolamine hydrochloride concentration was ca. 0.2 ng x ml(-1), both of which are levels known to be well tolerated in humans. Whole-blood cholinesterase inhibition was 15-20%. This regimen conferred full protection against 2.5 x LD50 i.v. of sarin. Albeit the high-dose exposure, cholinergic toxicity symptoms were mild with no convulsions. About 11-14 min following poisoning the treated animals started to walk and 15-20 min following exposure full recovery was observed and the dogs behaved normally. With higher dose rates of physostigmine salicylate and scopolamine hydrochloride, at plasma concentrations of 2.1 and 0.6 ng x ml(-1), respectively, treated dogs regained normal posture 6-10 min after exposure. Copyright 2001 John Wiley & Sons, Ltd.
机译：先前已经在豚鼠中评估了连续预防性施用毒扁豆碱和东pol碱对沙林诱导的毒性的保护作用。目前在大型动物中的研究使用了比格犬，它是一种胆碱能敏感性与人类相似的动物模型。通过Alzet微型渗透泵分别进行了2.5和1 microg x kg（-1）x h（-1）剂量比的水杨酸毒扁豆碱和盐酸东pol碱的预处理。在暴露时，血浆中毒扁豆碱水杨酸盐的浓度为0.7 ng x ml（-1），盐酸东pol碱的浓度为ca。 0.2 ng x ml（-1），这两种水平都是已知在人类中具有良好耐受性的水平。全血胆碱酯酶抑制率为15-20％。此方案可针对2.5 x LD50 i.v.提供全面保护。沙林尽管高剂量接触，胆碱能毒性症状轻微，无惊厥。中毒后约11-14分钟，被治疗的动物开始行走，并且在暴露后15-20分钟，观察到完全恢复，并且狗表现正常。在血浆浓度分别为2.1和0.6 ng x ml（-1）的情况下，使用高剂量的毒扁豆碱水杨酸盐和东碱盐酸盐剂量处理后，暴露的犬在6-10分钟后恢复了正常姿势。版权所有2001 John Wiley＆Sons，Ltd.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号