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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Polymer concepts in tissue engineering.
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Polymer concepts in tissue engineering.

机译：组织工程学中的聚合物概念。

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Traumatic injuries, cancer treatment, and congenital abnormalities are often associated with abnormal bone shape or segmental bone loss. Restoration of normal structure and function in these cases requires replacement of the missing bone that may be accomplished by surgical transfer of natural tissue from an uninjured location elsewhere in the body. However, this procedure is limited by availability, adequate blood supply, and secondary deformities at the donor site. One strategy to overcome these problems is to develop living tissue substitutes based on synthetic biodegradable polymers. Three methods of bone regeneration using biodegradable polymers are being studied in our laboratory: tissue induction, cell transplantation, and fabrication of vascularized bone flaps. Injectable polymers are used for filling skeletal defects and guiding bone tissue growth. Their main advantage is minimizing the surgical intervention or the severity of the surgery. Polymer-cell constructs also hold great promise in the field of tissue engineering. They provide a scaffold on which cells grow and organize themselves. As the cells begin to secrete their own extracellular matrix, the polymer degrades and is eventually eliminated from the body, resulting in completely natural tissue replacement. Bone flaps can be fabricated ectopically into precise shapes and sizes. With an attached vascular supply, these flaps can be transferred into areas deficient in vascularity. This article discusses polymer concepts regarding bone tissue engineering and reviews recent advances of our laboratory on guided bone regeneration using biodegradable polymer scaffolds.
机译：创伤，癌症治疗和先天性异常通常与异常的骨形或节段性骨丢失有关。在这些情况下，要恢复正常的结构和功能，就需要更换缺失的骨头，这可以通过将自然组织从身体其他部位未受伤的位置进行外科手术转移来完成。但是，该程序受到可用性，充足的血液供应和供体部位继发畸形的限制。克服这些问题的一种策略是开发基于合成的可生物降解聚合物的活组织替代品。我们实验室正在研究使用可生物降解的聚合物进行骨再生的三种方法：组织诱导，细胞移植和血管化骨瓣的制造。可注射聚合物用于填充骨骼缺损并引导骨骼组织生长。它们的主要优点是最大程度地减少了手术干预或手术的严重程度。聚合物细胞构建体在组织工程领域也具有广阔的前景。它们提供了一个支架，细胞可以在该支架上生长并自我组织。随着细胞开始分泌自己的细胞外基质，聚合物降解并最终从体内清除，导致完全自然的组织置换。骨瓣可以异位地制成精确的形状和大小。在附有血管供应的情况下，这些皮瓣可以转移到血管不足的区域。本文讨论了有关骨组织工程的聚合物概念，并回顾了我们实验室在使用可生物降解的聚合物支架进行引导性骨再生方面的最新进展。

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