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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Reduced blood flow in normal white matter predicts development of leukoaraiosis
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Reduced blood flow in normal white matter predicts development of leukoaraiosis

机译：正常白质中的血流量减少预示着白斑病的发展

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The purpose of this study was to investigate whether low cerebral blood flow (CBF) is associated with subsequent development of white matter hyperintensities (WMH). Patients were included from a longitudinal magnetic resonance (MR) imaging study of minor stroke/transient ischemic attack patients. Images were co-registered and new WMH at 18 months were identified by comparing follow-up imaging with baseline fluid-attenuated inversion recovery (FLAIR). Regions-of-interest (ROIs) were placed on FLAIR images in one of three categories: (1) WMH seen at both baseline and follow-up imaging, (2) new WMH seen only on follow-up imaging, and (3) regions of normal-appearing white matter at both time points. Registered CBF maps at baseline were used to measure CBF in the ROIs. A multivariable model was developed using mixed-effects logistic regression to determine the effect of baseline CBF on the development on new WMH. Forty patients were included. Mean age was 61 +/- 11 years, 30% were female. Low baseline CBF, female sex, and presence of diabetes were independently associated with the presence of new WMH on follow-up imaging. The odds of having new WMH on follow-up imaging reduces by 0.61 (95% confidence interval = 0.57 to 0.65) for each 1 mL/100 g per minute increase in baseline CBF. We conclude that regions of white matter with low CBF develop new WMH on follow-up imaging.
机译：这项研究的目的是调查低脑血流量（CBF）是否与随后的白质高信号（WMH）发生有关。患者被纳入了对中风/短暂性脑缺血发作患者的纵向磁共振成像研究。通过将随访影像与基线体液衰减反转恢复（FLAIR）进行比较，对图像进行了共配准并确定了18个月时的新WMH。将关注区域（ROI）放在以下三个类别之一的FLAIR图像上：（1）在基线和随访成像中均看到WMH，（2）仅在随访成像中看到新的WMH，以及（3）在两个时间点正常显示的白质区域。基线处注册的CBF图用于测量ROI中的CBF。使用混合效应对数回归开发了多变量模型，以确定基线CBF对新WMH的发展的影响。包括四十名患者。平均年龄为61 +/- 11岁，女性为30％。基线影像学检查发现低基线CBF，女性和糖尿病与新WMH的存在独立相关。基线CBF每增加1 mL / 100 g，在随访成像中使用新WMH的几率降低0.61（95％置信区间= 0.57至0.65）。我们得出的结论是，低脑血流的白质区域在随访影像学上发展出新的WMH。

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