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首页> 外文期刊>Journal of Perinatal Medicine >Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction.
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Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction.

机译：宫内生长受限孕妇妊娠胎盘中胰岛素样生长因子1，胰岛素样生长因子2和胰岛素样生长因子结合蛋白3的基因表达模式。

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INTRODUCTION: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR). MATERIALS AND METHODS: We compared 101 human placentas from intrauterine growth restriction pregnancies to those of 140 normal pregnancies treated at our department in a one-year period. We have also assessed the serum glucose and insulin levels of the IUGR and control groups. Several possible predicting factors of IUGR were also investigated. RESULTS: Risk for IUGR was suggested by gestational weight gain and gestational increase in maternal body mass index (BMI) as well as maternal birthweight. In pregnancies without IUGR, umbilical cord glucose and insulin levels were significantly higher than in pregnancies with IUGR. In placentas from pregnancies with IUGR an overexpression of the IGF-2 and the insulin-like growth factor binding protein (IGFBP)-3 genes was found. In placentas from pregnancies with male fetal gender we found a significant overexpression of the IGF-2 gene. DISCUSSION: Gestational weight gain and BMI increase seem to predict the development of IUGR. Insulin and carbohydrate metabolism are also impaired in IUGR fetuses. In the placentas from pregnancies with IUGR, IGF-2 is overexpressed reflecting its physiological role in optimizing energy distribution in a low-energy environment.
机译：引言：在这项研究中，我们比较了有或没有子宫内生长限制（IUGR）的妊娠人胎盘中胰岛素样生长因子（IGF）基因的表达模式以及葡萄糖和胰岛素代谢的特征。材料与方法：我们比较了一年内宫内生长受限妊娠的101例人胎盘与我科接受治疗的140例正常的胎盘。我们还评估了IUGR和对照组的血清葡萄糖和胰岛素水平。还研究了IUGR的几种可能的预测因素。结果：孕期体重增加和孕产妇体重指数（BMI）以及孕产妇出生体重的增加提示了IUGR的风险。在没有IUGR的孕妇中，脐带葡萄糖和胰岛素水平明显高于在IUGR的孕妇中。在患有IUGR的孕妇胎盘中，发现了IGF-2和胰岛素样生长因子结合蛋白（IGFBP）-3基因的过表达。在来自具有男性胎儿性别的怀孕的胎盘中，我们发现了IGF-2基因的显着过表达。讨论：妊娠期体重增加和BMI升高似乎预示了IUGR的发展。 IUGR胎儿的胰岛素和碳水化合物代谢也受到损害。在IGUR妊娠的胎盘中，IGF-2过度表达，反映出其在优化低能量环境中能量分配中的生理作用。

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