Solar keratoses: Photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, diclofenac, or what? Facts and controversies

SchmittA.R.; BordeauxJ.S.

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Solar keratoses: Photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, diclofenac, or what? Facts and controversies

机译：太阳角化病：光动力疗法，冷冻疗法，5-氟尿嘧啶，咪喹莫特，双氯芬酸或什么？事实与争议

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Abstract Actinic keratosis is a common dermatologic condition that may regress, remain stable, or progress to squamous cell carcinoma. Some question whether all actinic keratoses should be routinely treated, whereas others contend that the unpredictable natural history of this disease necessitates treatment to prevent malignant transformation. Available treatments include photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, and diclofenac. Each of these options has its advantages and disadvantages, although they all have a place in the management of actinic keratosis. An overview of these treatment modalities is presented, as are the controversies surrounding the treatment of actinic keratosis.

机译：摘要光化性角化病是一种常见的皮肤病，可能会消退，保持稳定或发展为鳞状细胞癌。一些人质疑是否应常规治疗所有光化性角化病，而另一些人则认为，这种疾病不可预测的自然病史需要治疗以预防恶性转化。可用的治疗方法包括光动力疗法，冷冻疗法，5-氟尿嘧啶，咪喹莫特和双氯芬酸。尽管它们在光化性角化病的治疗中都有其一席之地，但每种选择都有其优点和缺点。介绍了这些治疗方式的概述，以及围绕光化性角化病治疗的争议。

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《Clinics in dermatology》 |2013年第6期|共6页
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SchmittA.R.; BordeauxJ.S.;
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中图分类皮肤病学与性病学;
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1. Solar keratoses: Photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, diclofenac, or what? Facts and controversies [J] . SchmittA.R., BordeauxJ.S. Clinics in dermatology . 2013,第6期

机译：太阳角化病：光动力疗法，冷冻疗法，5-氟尿嘧啶，咪喹莫特，双氯芬酸或什么？事实与争议
2. Cost effectiveness of imiquimod 5% cream compared with methyl aminolevulinate-based photodynamic therapy in the treatment of non-hyperkeratotic, non-hypertrophic actinic (solar) keratoses: a decision tree model. [J] . Wilson EC PharmacoEconomics . 2010,第11期

机译：与基于氨基乙酰丙酸甲酯的光动力疗法相比，咪喹莫特5％乳膏治疗非角化过度，非肥大性光化性（太阳能）角化病的成本效益：决策树模型。
3. Treatment of Actinic Keratoses: A Randomized Split-Site Approach Comparison of Sequential 5-Fluorouracil and 5-Aminolevulinic Acid Photodynamic Therapy to 5-Aminolevulinic Acid Photodynamic Monotherapy [J] . Pei Susan, Kaminska Edidiong C. N., Tsoukas Maria M. Dermatologic surgery . 2017,第9期

机译：活体角膜的治疗：序贯5-氟尿嘧啶和5-氨基乙酸光动力治疗对5-氨基纤维酸光动力学单疗法的随机分裂部位比较
4. Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis [C] . Xiu-Li Wang, Hong-Wei Wang, Ming-Xia Guo, Biophotonics and Immune Responses II; Progress in Biomedical Optics and Imaging; vol.8 no.15; Proceedings of SPIE-The International Society for Optical Engineering; vol.6438 . 2007

机译：咪喹莫特免疫疗法和ALA光动力疗法联合治疗生殖器弓形丘疹
5. Efficacy of Combined 5-Fluorouracil and Photodynamic Therapy in Glioma Spheroids [D] . Singh, Karanjit 2018

机译：5-氟尿嘧啶联合光动力疗法治疗脑胶质瘤球体的疗效
6. An Investigator-initiated Study to Assess the Safety and Efficacy of Imiquimod 3.75 Cream When Used After Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses on Dorsal Hands and Forearms [O] . Gary Goldenberg, Rita V. Linkner, Giselle Singer, 2013

机译：一项由研究人员发起的研究用于评估冷冻疗法后使用咪喹莫特3.75％乳霜治疗背手和前臂肥大性光化性角化病的安全性和有效性
7. Effective Combination of Photodynamic Therapy and Imiquimod 5 Cream in the Treatment of Actinic Keratoses: Three Cases [O] . Laura Held, Thomas Kurt Eigentler, Ulrike Leiter, 2013

机译：光动力治疗和咪喹莫德5％乳膏的有效组合在疗法角膜治疗中：三种情况下

Solar keratoses: Photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, diclofenac, or what? Facts and controversies

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