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首页> 外文期刊>Journal of studies on alcohol >Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction.
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Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction.

机译：婚姻状况，酒精依赖和GABRA2：基因与环境相关和相互作用的证据。

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OBJECTIVE: The gene GABRA2 has been associated with the risk for alcohol dependence in independent samples. This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence. METHOD: Data from more than 1,900 male and female subjects from the Collaborative Study of the Genetics of Alcoholism (COGA) sample were analyzed. Subjects were recruited based on membership in a family with multiple individuals with alcoholism. A series of analyses was performed to evaluate the relationship between the following: (1) GABRA2 and alcohol dependence, (2) marital status and alcohol dependence, (3) GABRA2 and marital status, and (4) interactions between GABRA2 and marital status on the development of alcohol dependence in the high-risk COGA sample. Additional analyses were carried out in a sample of approximately 900 individuals from control families to test the generalizability of results. RESULTS: Both GABRA2 and marital status contributed independently to the development of alcohol dependence in the COGA sample. The high-risk genotype at GABRA2 was also related to a decreased likelihood of marrying and an increased likelihood of divorce, which appeared to be mediated in part by personality characteristics. There was also differential risk associated with the GABRA2 genotype according to marital status. CONCLUSIONS: These analyses provide evidence of both gene-environment correlation and gene-environment interaction associated with GABRA2, marital status, and alcohol dependence. They illustrate the complex pathways by which genotype and environmental risk factors act and interact to influence alcohol dependence and challenge traditional conceptualizations of "environmental" risk factors.
机译：目的：GABRA2基因与独立样本中酒精依赖的风险有关。本文探讨了这种遗传风险因素如何与婚姻状况（先前显示与酒精依赖风险有关的另一因素）相互作用。方法：分析了来自酗酒遗传学合作研究（COGA）样本的1,900多名男性和女性受试者的数据。根据多人酗酒的家庭成员资格招募受试者。进行了一系列分析以评估以下各项之间的关系：（1）GABRA2与酒精依赖，（2）婚姻状况与酒精依赖，（3）GABRA2与婚姻状况，以及（4）GABRA2与婚姻状况之间的相互作用高风险COGA样品中酒精依赖的发展。在来自对照家族的大约900个个体的样本中进行了其他分析，以测试结果的普遍性。结果：GABRA2和婚姻状况均独立影响了COGA样本中酒精依赖的发展。 GABRA2的高风险基因型还与结婚的可能性降低和离婚的可能性增加有关，这似乎部分是由人格特征介导的。根据婚姻状况，GABRA2基因型也存在差异风险。结论：这些分析提供了与GABRA2，婚姻状况和酒精依赖相关的基因-环境相关性和基因-环境相互作用的证据。他们阐明了基因型和环境危险因素相互作用和相互作用以影响酒精依赖并挑战传统的“环境”危险因素概念化的复杂途径。

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