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首页> 外文期刊>American Journal of Physiology >Age-dependent regression analysis of male gonadal axis.
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Age-dependent regression analysis of male gonadal axis.

机译：男性性腺轴的年龄依赖性回归分析。

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The mechanisms by which aging progressively depletes testosterone (Te) availability in the male are unknown. Accordingly, the objective was to estimate brain gonadotropin-releasing hormone (GnRH) outflow (release and action), which cannot be observed directly, on the basis of downstream effects on pituitary luteinizing hormone (LH) secretion. LH, in turn, feeds forward on (stimulates) gonadal Te secretion, which then feeds back on (inhibits) GnRH-driven LH secretion. LH and Te concentrations were measured repetitively (every 10 min) over 18 h during graded pharmacological blockade of endogenous GnRH outflow in 24 healthy 20- to 72-yr-old men. Data were analyzed using a new age-dependent regression model of GnRH-LH-Te interactions to estimate pulsatile LH secretion and elimination, GnRH outflow, LH feedforward, and Te feedback. By incorporating regression on age within the dose-response model, we show that aging erodes all three primary forward and reverse pathways linking the brain, pituitary gland, and testes. Aging is associated with concomitant deficits in GnRH --> LH feedforward, LH --> Te feedforward, and Te --> GnRH/LH feedback. The analytical formalism should be generalizable to other ensemble regulatory systems, such as those that control growth, reproduction, stress adaptations, and glucose metabolism.
机译：衰老逐渐消耗男性睾丸激素（Te）的机制尚不清楚。因此，目的是根据对垂体促黄体生成激素（LH）分泌的下游影响，估计无法直接观察到的脑促性腺激素释放激素（GnRH）流出（释放和作用）。反过来，LH会前馈（刺激）性腺Te分泌，然后再反馈（抑制）GnRH驱动的LH分泌。在24例20至72岁健康男性的内源性GnRH流出的分级药理阻滞过程中，在18小时内重复（每10分钟）测量LH和Te浓度。使用新的年龄相关的GnRH-LH-Te相互作用回归模型对数据进行分析，以估计搏动性LH分泌和消除，GnRH流出，LH前馈和Te反馈。通过在剂量反应模型中纳入年龄回归，我们表明衰老侵蚀了连接大脑，垂体和睾丸的所有三个主要正向和反向通路。衰老与GnRH-> LH前馈，LH-> Te前馈和Te-> GnRH / LH反馈的伴随缺陷有关。分析形式主义应该可以推广到其他整体调节系统，例如那些控制生长，繁殖，压力适应和葡萄糖代谢的系统。

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