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首页> 外文期刊>American Journal of Physiology >Age-dependent regression analysis of male gonadal axis.
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Age-dependent regression analysis of male gonadal axis.

机译：雄性腺轴的年龄依赖性回归分析。

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摘要

The mechanisms by which aging progressively depletes testosterone (Te) availability in the male are unknown. Accordingly, the objective was to estimate brain gonadotropin-releasing hormone (GnRH) outflow (release and action), which cannot be observed directly, on the basis of downstream effects on pituitary luteinizing hormone (LH) secretion. LH, in turn, feeds forward on (stimulates) gonadal Te secretion, which then feeds back on (inhibits) GnRH-driven LH secretion. LH and Te concentrations were measured repetitively (every 10 min) over 18 h during graded pharmacological blockade of endogenous GnRH outflow in 24 healthy 20- to 72-yr-old men. Data were analyzed using a new age-dependent regression model of GnRH-LH-Te interactions to estimate pulsatile LH secretion and elimination, GnRH outflow, LH feedforward, and Te feedback. By incorporating regression on age within the dose-response model, we show that aging erodes all three primary forward and reverse pathways linking the brain, pituitary gland, and testes. Aging is associated with concomitant deficits in GnRH --> LH feedforward, LH --> Te feedforward, and Te --> GnRH/LH feedback. The analytical formalism should be generalizable to other ensemble regulatory systems, such as those that control growth, reproduction, stress adaptations, and glucose metabolism.
机译：老化逐渐消耗睾酮（TE）在雄性中的可用性的机制是未知的。因此，目的是在垂体叶丁骨激素（LH）分泌的下游作用的基础上，估计脑促性腺激素释放激素（GnRH）流出（GNRH）流出（释放和动作）。反过来，直接喂食（刺激）Gonadal Te分泌，然后喂回（抑制）GnRH驱动的LH分泌。 LH和TE浓度在24个健康的20至72岁至72岁男性中，重复地（每10分钟）在18小时内以超过18小时测量。使用GNRH-LH-TE相互作用的新年龄依赖性回归模型进行分析数据，以估计脉冲LH分泌和消除，GNRH流出，LH馈电和TE反馈。通过在剂量响应模型内掺入年龄的回归，我们表明老化侵蚀了连接大脑，脑垂体和睾丸的所有三个主要前进和反向通路。老化与GNRH - > LH Feedforward，LH - > TE Feedforward和Te - > Gnrh / LH反馈中的伴随缺陷有关。分析形式主义应该普遍地允许其他集合调节系统，例如控制生长，繁殖，应力适应和葡萄糖代谢的那些。

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