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首页> 外文期刊>Critical reviews in clinical laboratory sciences >The role of human papillomavirus in gynecological diseases.
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The role of human papillomavirus in gynecological diseases.

机译：人乳头瘤病毒在妇科疾病中的作用。

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Papanicolaou (Pap) smears of the cervix and biopsies of the cervix, vagina, vulva, and penis are a substantial portion of the work load of any anatomic pathology laboratory. The importance of samples from these sites is highlighted by the fact that their most common disease is dysplasia, which is sexually transmitted and a recognized risk factor for carcinoma. Human papillomavirus (HPV) is an essential co-factor for the development of lower genital tract dysplasia. Molecular testing for HPV has revealed a great deal about the pathophysiology of dysplasia and its evolution to carcinoma. Importantly, it now allows diagnostic pathologists the opportunity to be more accurate in their assessment of common conditions such as Pap smears of squamous atypia and biopsies equivocal for dysplasia. This review highlights the role of HPV in the evolution of disease in the lower genital tract and stresses the utility of HPV testing to the diagnostic pathologist.
机译：子宫颈的巴氏涂片和子宫颈，阴道，外阴和阴茎的活检是任何解剖病理学实验室工作量的重要部分。这些部位最常见的疾病是发育不良，这是通过性传播和公认的癌症危险因素，这一事实凸显了来自这些部位的样本的重要性。人乳头瘤病毒（HPV）是下生殖道发育不良的重要辅助因素。 HPV的分子测试已揭示了关于发育异常及其演变成癌的大量病理生理学信息。重要的是，它现在使诊断病理学家有机会更准确地评估常见状况，例如鳞状非典型性肺炎的子宫颈抹片涂片和明显的不典型增生的活检。这篇综述强调了HPV在下生殖道疾病演变中的作用，并向诊断病理学家强调了HPV检测的实用性。

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