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Anti-diphtheria immunity in Nigerian mothers and their newborns

机译：尼日利亚母亲及其新生儿的抗白喉免疫力

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Background: Immunity to diphtheria has been noted to wane with age such that previous studies have shown that a significant proportion of females with characteristics comparable to those of Nigerian women of reproductive age have inadequate levels of immunity to diphtheria. Thus, it is envisaged that Nigerian newborns may inherit inadequate levels of immunity to diphtheria from their mothers. Methods: Cord blood and peripheral maternal blood samples were collected from 231 mother-infant pairs at delivery. Anti-diphtheria antibody titres were assayed using Enzyme-linked immunosorbent assay (ELISA) technique. Recruited babies were those born at term with normal birth weight. Results: As much as 29.9% of both mothers and their babies had no protection (antibody titre < 0.01 IU/ml) from diphtheria. Ninety (39.0% CI 33%,45%) mothers and 107(46.3% CI 40%,52%) babies were inadequately protected (antibody titre < 0.1 IU/ml) from diphtheria. The difference in the geometric mean antibody titres of mothers and babies was statistically significant (p < 0.0001). There was a strong positive linear correlation between maternal and newborn antibody titres ("r" = 0.983, p < 0.0001), such that, as mothers antibody titres increased those of their babies also increased. Conclusion: Significant proportions of Nigerian mothers and newborns are at risk of developing diphtheria. Vaccination of parturient women with booster doses of diphtheria toxoid vaccine is recommended
机译：背景：人们已经注意到白喉的免疫力随着年龄的增长而减弱，因此以前的研究表明，与尼日利亚育龄妇女的特征相当的女性中，白喉的免疫力水平不足。因此，可以设想，尼日利亚新生儿可能从母亲那里继承了对白喉免疫力不足的水平。方法：分娩时从231对母婴中采集脐带血和外周血。使用酶联免疫吸附测定（ELISA）技术测定抗白喉抗体滴度。应征婴儿是指足月出生时体重正常的婴儿。结果：多达29.9％的母亲和婴儿都没有白喉的保护作用（抗体滴度<0.01 IU / ml）。九十名（39.0％CI 33％，45％）的母亲和107名（46.3％CI 40％，52％）的婴儿没有受到白喉的保护（抗体滴度<0.1 IU / ml）。母亲和婴儿的几何平均抗体滴度差异具有统计学意义（p <0.0001）。母体和新生儿抗体滴度之间存在很强的线性正相关（“ r” = 0.983，p <0.0001），因此，随着母亲抗体滴度的增加，其婴儿的抗体滴度也随之增加。结论：很大比例的尼日利亚母亲和新生儿有患白喉的风险。建议用加强剂量的白喉类毒素疫苗对产妇进行疫苗接种

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