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首页> 外文期刊>Nano letters >Photodynamic Therapy with Liposomes Encapsulating Photosensitizers with Aggregation-Induced Emission
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Photodynamic Therapy with Liposomes Encapsulating Photosensitizers with Aggregation-Induced Emission

机译：用脂质体用聚集诱导的发射包封光敏剂的光动力学疗法

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摘要

As a noninvasive treatment, photodynamic therapy (PDT) is a promising strategy against tumors. It is based on photosensitizer (PS)-induced phototoxicity after irradiation. However, most clinically approved PSs will be widely distributed in normal tissues, especially in the skin, where they will induce phototoxicity on exposure to light. Therefore, patients must remain in a dark room for up to several weeks during or after a PDT. Herein, we proposed a strategy of aggregation -induced emission PSs (AIE-PSs) entrapped in liposomes with controlled photosensitization. The AIE-PSs begin to lose their photosensitivity when entrapped in liposomes. After liposomes have carried AIE-PSs into tumor tissues, the AIE-PSs will be released and immediately reaggregate in a targeted area as the liposomes are decomposed. Their photosensitivity can be triggered at turn-on state and induce cytotoxicity. Two different types of AIE molecules were synthesized and entrapped by liposomes, respectively, to verify the PDT features against tumors in vitro and in vivo. The results indicate that, using this strategy, the photosensitivity of AIE-PS can be controlled and PDT can be treated under normal working conditions, not necessarily in a dark room.
机译：作为一种非侵入性治疗，光动力治疗（PDT）是对肿瘤的有希望的策略。它基于光敏剂（PS） - 照射后诱导的光毒性。然而，大多数临床批准的PSS将广泛分布在正常组织中，特别是在皮肤上，在那里它们会在暴露于光线上诱导光毒性。因此，患者必须在PDT期间或之后留在暗室中长达几周。在此，我们提出了具有受控光敏的脂质体捕获的聚集诱导的发射PSS（AIE-PSS）的策略。当夹住脂质体时，AIE-PSS开始失去光敏性。脂质体使AIE-PSS载入肿瘤组织后，将释放AIE-PSS并立即在脂质体分解时立即重新生成靶向区域。它们的光敏性可以在导通状态下触发并诱导细胞毒性。通过脂质体合成两种不同类型的AIE分子，以验证对肿瘤的PDT特征在体外和体内。结果表明，使用该策略，可以控制AIE-PS的光敏性，并且可以在正常工作条件下处理PDT，不一定在暗室中。

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  • 来源
    《Nano letters》 |2019年第3期|共6页
  • 作者

    Yang Yang; Wang Lei; Cao Hongqian; Li Qi; Li Ying; Han Mingjuan; Wang Hao; Li Junbai;

  • 作者单位

    Natl Ctr Nanosci &

    Technol CAS Key Lab Biomed Effects Nanomat &

    Nanosafety Beijing 100190 Peoples R China;

    Natl Ctr Nanosci &

    Technol CAS Key Lab Biomed Effects Nanomat &

    Nanosafety Beijing 100190 Peoples R China;

    Natl Ctr Nanosci &

    Technol CAS Key Lab Biomed Effects Nanomat &

    Nanosafety Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Colloid &

    Interface Sci BNLMS Beijing 100190 Peoples R China;

    Natl Ctr Nanosci &

    Technol CAS Key Lab Biomed Effects Nanomat &

    Nanosafety Beijing 100190 Peoples R China;

    Nanjing Tech Univ Coll Chem &

    Mol Engn Nanjing Jiangsu Peoples R China;

    Natl Ctr Nanosci &

    Technol CAS Key Lab Biomed Effects Nanomat &

    Nanosafety Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem Key Lab Colloid &

    Interface Sci BNLMS Beijing 100190 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;物理化学（理论化学）、化学物理学;
  • 关键词

    liposome; aggregation-induced emission; self-assembly; photodynamic therapy; bis(pyrene);

    机译：脂质体;聚集诱导的发射;自组装;光动力疗法;双（芘）;

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