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首页> 外文期刊>Acta biomaterialia >Collagen for bone tissue regeneration
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Collagen for bone tissue regeneration

机译：骨组织再生胶原蛋白

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In the last decades, increased knowledge about the organization, structure and properties of collagen (particularly concerning interactions between cells and collagen-based materials) has inspired scientists and engineers to design innovative collagen-based biomaterials and to develop novel tissue-engineering products. The design of resorbable collagen-based medical implants requires understanding the tissue/organ anatomy and biological function as well as the role of collagen's physicochemical properties and structure in tissue/organ regeneration. Bone is a complex tissue that plays a critical role in diverse metabolic processes mediated by calcium delivery as well as in hematopoiesis whilst maintaining skeleton strength. A wide variety of collagen-based scaffolds have been proposed for different tissue engineering applications. These scaffolds are designed to promote a biological response, such as cell interaction, and to work as artificial biomimetic extracellular matrices that guide tissue regeneration. This paper critically reviews the current understanding of the complex hierarchical structure and properties of native collagen molecules, and describes the scientific challenge of manufacturing collagen-based materials with suitable properties and shapes for specific biomedical applications, with special emphasis on bone tissue engineering. The analysis of the state of the art in the field reveals the presence of innovative techniques for scaffold and material manufacturing that are currently opening the way to the preparation of biomimetic substrates that modulate cell interaction for improved substitution, restoration, retention or enhancement of bone tissue function.
机译：在过去的几十年中，对胶原的组织，结构和特性（尤其是有关细胞与基于胶原的材料之间的相互作用）的了解增加，激发了科学家和工程师设计创新的基于胶原的生物材料并开发出新颖的组织工程产品。基于可吸收胶原的医用植入物的设计需要了解组织/器官的解剖结构和生物学功能，以及胶原的理化性质和结构在组织/器官再生中的作用。骨骼是一种复杂的组织，在钙传递介导的各种代谢过程以及造血过程中起着至关重要的作用，同时又保持骨骼强度。已经提出了多种基于胶原的支架用于不同的组织工程应用。这些支架旨在促进生物反应，例如细胞相互作用，并充当指导组织再生的人工仿生细胞外基质。本文批判性地回顾了对天然胶原分子的复杂层次结构和特性的当前理解，并描述了制造具有特定生物学特性的适当特性和形状的胶原基材料的科学挑战，其中特别强调了骨组织工程。对本领域现有技术的分析表明，存在用于脚手架和材料制造的创新技术，这些技术目前为制备仿生底物开辟了道路，该仿生底物可调节细胞相互作用以改善骨组织的替代，修复，保留或增强作用功能。

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