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首页> 外文期刊>Acta biomaterialia >Influence of hydration on fiber geometry in electrospun scaffolds
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Influence of hydration on fiber geometry in electrospun scaffolds

机译：水合对电纺支架中纤维几何形状的影响

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Finite element models of tissue engineering scaffolds are powerful tools to understand scaffold function, including how external mechanical signals deform the scaffold at the meso- and microscales. Fiber geometry is needed to inform finite element models of fiber-based tissue engineering scaffolds; however, the accuracy and utility of these models may be limited if they are informed by non-hydrated geometries. Scanning electron microscopy and confocal microscopy, coupled with Fourier analysis of the resulting images, were used to quantify how hydration alters fiber geometry in electrospun collagen and polycaprolactone (PCL) scaffolds. The results also quantify how image size affects fiber geometry. Hydration is demonstrated to increase fiber tortuosity, defined as the ratio of actual fiber length:end-to-end fiber length. For collagen scaffolds, hydration increased the mean tortuosity from 1.05 to 1.21, primarily from large ～2- to 10-fold) increases in smaller (<40 μm) wavelength amplitudes. For PCL fibers, the mean tortuosity increased from 1.01 to only 1.04, primarily from modest ～2-fold) increases in larger (>100 μm) wavelength amplitudes. The results demonstrate that mechanical simulations of electrospun scaffolds should be informed with hydrated scaffold geometries of at least 200 μm scale, in order to capture geometrical effects associated with fiber straightening.
机译：组织工程支架的有限元模型是了解支架功能的强大工具，包括外部机械信号如何在中尺度和微观尺度上使支架变形。需要纤维几何形状来告知基于纤维的组织工程支架的有限元模型;但是，如果通过非水合几何形状告知这些模型，则其准确性和实用性可能会受到限制。扫描电子显微镜和共聚焦显微镜，再对所得图像进行傅立叶分析，用于量化水合作用如何改变电纺胶原蛋白和聚己内酯（PCL）支架中的纤维几何形状。结果还量化了图像尺寸如何影响光纤的几何形状。证明水合会增加纤维的曲折度，定义为实际纤维长度与端对端纤维长度之比。对于胶原蛋白支架，水合作用将平均曲折度从1.05增加到1.21，主要是从大的2倍增加到10倍），在较小的（<40μm）波长范围内增加。对于PCL光纤，平均曲折度从1.01增加到仅1.04，主要是从较大的（> 100μm）波长幅度增加到2倍。结果表明，电纺脚手架的机械模拟应以至少200μm规模的水合脚手架几何形状为基础，以便捕获与纤维拉直相关的几何效应。

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