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首页> 外文期刊>Biochemical Genetics >TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population
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TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population

机译：基于中国汉族慢性乙型肝炎感染的基于慢性乙型肝炎感染的TNIP1多态性

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Chronic hepatitis B virus (HBV) infection is an important etiology for the development of hepatocellular carcinoma (HCC). Tumor necrosis factor--induced protein 3-interacting protein 1 (TNIP1) is linked to specific inflammatory diseases as a novel type of endogenous inflammatory regulator. However, presently, rare information is found about the association between TNIP1 polymorphisms and HBV-induced HCC risk. In this case control study, we genotyped four single nucleotide polymorphisms (SNPs) in TNIP1 gene in 248 HCC patients and 242 chronic HBV carriers using Sequenom Mass-ARRAY technology. Genetic model and haplotype analysis were performed to evaluate the association between candidate SNPs polymorphisms and HBV-induced HCC susceptibility using Pearson's (2) test and unconditional logistic regression analysis. Overall, we found two risk alleles in TNIP1 for HBV-induced HCC in patients: the allele G of rs7708392 by genotype model (G/C vs. C/C: OR 1.88, 95% CI 1.17-3, P=0.009) and dominant model (G/C-G/G vs. C/C: OR 1.69, 95% CI 1.08-2.65, P=0.023), and the allele C of rs10036748 by genotype model (C/T vs. T/T: OR 1.83, 95% CI 1.14-2.92, P=0.012) and dominant model (C/T-C/C vs. T/T: OR 1.65, 95% CI 1.05-2.59, P=0.03). However, rs3792792 and rs4958881 polymorphisms didn't significantly correlate with the risk of HBV-induced HCC. Haplotype analysis showed no significant association between haplotypes and the HCC risk in HBV carriers. This study provides evidence for HBV-induced HCC susceptibility gene TNIP1 in the Chinese Han population.
机译：慢性乙型肝炎病毒（HBV）感染是肝细胞癌（HCC）发育的重要病因。肿瘤坏死因子诱导的蛋白3-相互作用蛋白1（TNIP1）与特异性炎性疾病连接为一种新型的内源性炎症调节剂。然而，目前，发现了罕见的信息是关于TNIP1多态性和HBV诱导的HCC风险之间的关联。在这种情况下，在248例HCC患者和242例慢性HBV载体中，我们在TNIP1基因中进行了四种单一核苷酸多态性（SNP）的四种单一核苷酸多态性（SNP）。进行遗传模型和单倍型分析，以评价候选SNPs多态性与HBV诱导的HCC敏感性的关联，使用Pearson（2）试验和无条件逻辑回归分析。总体而言，我们在患者的HBV诱导的HCC中发现了两种风险等位基因：基因型模型的等位基因G rs7708392（G / C与C / C：或1.88,95％CI 1.17-3，P = 0.009）和主导模型（G / Cg / g与C / C：或1.69,95％CI 1.08-2.65，p = 0.023），基因型模型和Rs10036748的等位基因C（C / T与T / T：或1.83 ，95％CI 1.14-2.92，P = 0.012）和显性模型（C / TC / C与T / T：或1.65,95％CI 1.05-2.59，P = 0.03）。然而，RS3792792和RS4958881多态性与HBV诱导的HCC的风险没有显着相关。单倍型分析显示HBV载体中单型和HCC风险之间没有显着关联。本研究为中国汉族人群中HBV诱导的HCC易感性基因TNIP1提供了证据。

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