Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

Ducrocq Fabien; Walle Roman; Contini Andrea; Oummadi Asma; Caraballo Baptiste; van der Veldt Suzanne; Boyer Marie-Lou; Aby Frank; Tolentino-Cortez Tarson; Helbling Jean-Christophe; Martine Lucy; Gregoire Stephane; Cabaret Stephanie; Vancassel Sylvie; Laye Sophie; Kang Jing Xuan; Fioramonti Xavier; Berdeaux Olivier; Barreda-Gomez Gabriel; Masson Elodie; Ferreira Guillaume; Ma David W. L.; Bosch-Bouju Clementine; De Smedt-Peyrusse Veronique; Trifilieff Pierre

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Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

机译：N-3多不饱和脂肪酸缺乏和动机缺陷之间的因果关系

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Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational impairments. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) onto dopamine D1 receptor-expressing MSNs in the nucleus accumbens, a main brain region for the modulation of motivation. Strikingly, transgenically preventing n-3 PUFA deficiency selectively in D2-expressing neurons normalizes MSN collateral inhibition and enhances motivation. These results constitute the first demonstration of a causal link between a behavioral deficit and n-3 PUFA decrease in a discrete neuronal population and suggest that lower n-3 PUFA biostatus in psychopathologies could participate in the etiology of reward-related symptoms.

机译：奖励处理障碍是几种精神疾病的常见症状。但是，潜在的病理机制是否常见是未知的。在此，我们询问N-3多不饱和脂肪酸（PUFA）脂质物种的降低是否始终描述于这些病理学中，可以提高奖励处理缺陷。我们表明，小鼠中的N-3 Pufa Biostatus降低导致选择性励志障碍。电生理记录揭示了多巴胺D2受体表达培养基刺（D2-MSNS）对核心腺中的多巴胺D1受体 - 表达MSN的增加的抵押品抑制，是用于调节动机的主要脑区。尖锐的是，在D2表达神经元中有选择性地重原预防N-3 PUFA缺乏，使MSN抵押品抑制标准化并增强动机。这些结果构成了行为缺陷和N-3 PUFA之间存在离散神经元群体之间的因果关系的第一次演示，并表明PSPockologies的低N-3 Pufa Biostatus可以参与奖励相关症状的病因。

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《Cell metabolism》 |2020年第4期|共25页
作者
Ducrocq Fabien; Walle Roman; Contini Andrea; Oummadi Asma; Caraballo Baptiste; van der Veldt Suzanne; Boyer Marie-Lou; Aby Frank; Tolentino-Cortez Tarson; Helbling Jean-Christophe; Martine Lucy; Gregoire Stephane; Cabaret Stephanie; Vancassel Sylvie; Laye Sophie; Kang Jing Xuan; Fioramonti Xavier; Berdeaux Olivier; Barreda-Gomez Gabriel; Masson Elodie; Ferreira Guillaume; Ma David W. L.; Bosch-Bouju Clementine; De Smedt-Peyrusse Veronique; Trifilieff Pierre;
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Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

IMG Pharma Biotech SL Res Dept BIC Bizkaia 612 Derio 48160 Spain;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bourgogne Franche Comte Ctr Sci Gout &

Alimentat INRAE AgroSup Dijon CNRS F-21000 Dijon;

Univ Bourgogne Franche Comte Ctr Sci Gout &

Alimentat INRAE AgroSup Dijon CNRS F-21000 Dijon;

Univ Bourgogne Franche Comte Ctr Sci Gout &

Alimentat INRAE AgroSup Dijon CNRS F-21000 Dijon;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Massachusetts Gen Hosp Lab Lipid Med &

Technol Boston MA 02114 USA;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bourgogne Franche Comte Ctr Sci Gout &

Alimentat INRAE AgroSup Dijon CNRS F-21000 Dijon;

IMG Pharma Biotech SL Res Dept BIC Bizkaia 612 Derio 48160 Spain;

Univ Bourgogne Franche Comte Ctr Sci Gout &

Alimentat INRAE AgroSup Dijon CNRS F-21000 Dijon;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Guelph Dept Human Hlth &

Nutr Sci 50 Stone Rd E Guelph ON N1G 2W1 Canada;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

Univ Bordeaux NutriNeuro Bordeaux INP INRAE F-33000 Bordeaux France;

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中图分类内分泌腺疾病及代谢病;
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专利

1. Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits [J] . Ducrocq Fabien, Walle Roman, Contini Andrea, Cell metabolism . 2020,第4期

机译：N-3多不饱和脂肪酸缺乏和动机缺陷之间的因果关系
2. In Male Rats with Concurrent Iron and (n-3) Fatty Acid Deficiency, Provision of Either Iron or (n-3) Fatty Acids Alone Alters Monoamine Metabolism and Exacerbates the Cognitive Deficits Associated with Combined Deficiency [J] . Jeannine Baumgartner47*, Cornelius M. Smuts7, Linda Malan7, The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2012,第8期

机译：在患有铁和（n-3）脂肪酸缺乏症的雄性大鼠中，单独提供铁或（n-3）脂肪酸会改变单胺代谢并加剧与联合缺乏症相关的认知缺陷
3. Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio (corrected) of alpha-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. [J] . Welch AA, Shakya Shrestha S, Lentjes MA, The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition . 2010,第5期

机译：吃鱼和不吃鱼的肉食者，素食主义者和素食主义者的饮食中n-3多不饱和脂肪酸的摄入量和状况以及α-亚麻酸与长链的乘积比（校正） n-3多不饱和脂肪酸：来自EPIC-Norfolk研究组。
4. Quantitative Profiling of Metabolites of Polyunsaturated Fatty Acids Modulated by Dietary N-3 Deficiency in Rat Lung Tissues by HPLC/ESI-MS/MS [C] . Jeongrim Lee, Kei Hamazaki, Hee-Yong Kim ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：HPLC / ESI-MS / MS膳食N-3缺乏膳食N-3缺陷调节多不饱和脂肪酸代谢物的定量分析
5. Effect of N-3 and N-6 polyunsaturated fatty acids on inflammation [D] . Xu, Tao 2017

机译：N-3和N-6多不饱和脂肪酸对炎症的影响
6. A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol ISRCTN72331636 [O] . Alan D Dangour, Felicity Clemens, Diana Elbourne, 2006

机译：一项随机对照试验研究补充n-3长链多不饱和脂肪酸对认知健康的老年人的认知和视网膜功能的影响：老年人和n-3长链多不饱和脂肪酸（OPAL）研究方案ISRCTN72331636
7. Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits [O] . Fabien Ducrocq, Roman Walle, Andrea Contini, 2020

机译：N-3多不饱和脂肪酸缺乏和动机缺陷之间的因果关系

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

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