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Epithelial cell plasticity defines heterogeneity in lung cancer

机译：上皮细胞塑性在肺癌中定义异质性

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Lung cancer is the leading cause of cancer death for both men and women and accounts for almost 18.4% of all deaths due to cancer worldwide, with the global incidence increasing by approximately 0.5% per year. Lung cancer is regarded as a devastating type of cancer owing to its high prevalence, reduction in the health-related quality of life, frequently delayed diagnosis, low response rate, high toxicity, and resistance to available therapeutic options. The highly heterogeneous nature of this cancer with a proximal-to-distal distribution throughout the respiratory tract dramatically affects its diagnostic and therapeutic management. The diverse composition and plasticity of lung epithelial cells across the respiratory tract are regarded as significant factors underlying lung cancer heterogeneity. Therefore, definitions of the cells of origin for different types of lung cancer are urgently needed to understand lung cancer biology and to achieve early diagnosis and develop cell-targeted therapies. In the present review, we will discuss the current understanding of the cellular and molecular alterations in distinct lung epithelial cells that result in each type of lung cancer.
机译：肺癌是男女癌症死亡的主要原因，占全世界癌症的近18.4％的近18.4％，全球发病率每年增加约0.5％。由于其患病率高，肺癌患病率高，肺癌被认为是一种毁灭性的癌症类型，减少了与健康相关的生活质量，经常延迟诊断，低响应率，高毒性以及对可用治疗方案的抵抗力。这种癌症在整个呼吸道中具有近端远端分布的高度异质性，显着影响其诊断和治疗管理。肺部流道肺上皮细胞的不同组成和可塑性被认为是肺癌异质性下面的重要因素。因此，迫切需要对不同类型的肺癌进行原产地的细胞的定义，以了解肺癌生物学并实现早期诊断和发展细胞靶向疗法。在本综述中，我们将讨论目前了解导致每种类型肺癌的不同肺上皮细胞中细胞和分子改变的理解。

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