Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis

Bangham Charles R. M.

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Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis

机译：人T细胞白血病病毒类型1：持续和发病机制

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Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related lentivirus HIV-1, HTLV-1 causes disease in only 5-10% of infected people, depending on their ethnic origin. But whereas HIV-1 infection and the consequent diseases can be efficiently contained in most cases by antiretroviral drug treatment, there is no satisfactory treatment for the malignant or inflammatory diseases caused by HTLV-1. The purpose of the present article is to review recent advances in the understanding of the mechanisms by which the virus persists in vivo and causes disabling or fatal diseases.

机译：人T细胞白血病病毒类型1（HTLV-1），也称为人T龙眼病毒1型，是第一个发现的外源人逆转录病毒。与远处相关的慢病毒HIV-1不同，HTLV-1仅在5-10％的感染者中引起疾病，具体取决于他们的族裔。但是，在大多数情况下，HIV-1感染和随后的疾病可以通过抗逆转录病毒药物治疗有效地含有含量的恶性或炎症性疾病的令人满意的治疗方法。本文的目的是审查最近理解病毒在体内持续的机制的进步，并导致致残或致命疾病。

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《Annual Review of Immunology》 |2018年第2018期|共29页
作者
Bangham Charles R. M.;
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作者单位

Imperial Coll Fac Med Div Infect Dis London W2 1PG England;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
HTLV-1; retrovirus; latency; ATL; HAM/TSP;

机译：HTLV-1;逆转录病毒;延迟;atl;火腿/茶;

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专利

1. Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis [J] . Bangham Charles R. M. Annual Review of Immunology . 2018,第期

机译：人T细胞白血病病毒类型1：持续和发病机制
2. Human oncoviruses: Mucocutaneous manifestations, pathogenesis, therapeutics, and prevention Hepatitis viruses, human T-cell leukemia viruses, herpesviruses, and Epstein-Barr virus [J] . Mui Uyen Ngoc, Haley Christopher T., Vangipuram Ramya, Journal of the American Academy of Dermatology . 2019,第1期

机译：人的卵巢病毒：粘整体表现，发病机制，治疗和预防肝炎病毒，人T细胞白血病病毒，疱疹病毒和彭斯坦 - 巴尔病毒
3. Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence [J] . Alexandre Carpentier, Alix de Brogniez, David Boehr, Viruses . 2015,第7期

机译：人类T细胞白血病病毒1型传播，复制和持久性的模式
4. Tumorigenesis With Transgenic Expression of Human T/cell Leukemia Virus Tax [C] . Lee Ratner Japanese Cancer Association . 2003

机译：具有人T /细胞白血病病毒税的转基因表达的肿瘤
5. Lipid rafts, exosomes, and human T-cell leukemia virus type 1 biology: A new model of viral pathogenesis. [D] . Niyogi, Kakoli. 2003

机译：脂质筏，外来体和人类T细胞白血病病毒1型生物学：病毒发病机制的新模型。
6. Lymphoid Organs as a Major Reservoir for Human T-Cell Leukemia Virus Type 1 in Experimentally Infected Squirrel Monkeys (Saimiri sciureus): Provirus Expression Persistence and Humoral and Cellular Immune Responses [O] . Mirdad Kazanji, Abel Ureta-Vidal, Simona Ozden, 2000

机译：淋巴器官作为实验性感染的松鼠猴（Saimiri sciureus）中人T细胞白血病病毒1型的主要储存库：原病毒表达持久性以及体液和细胞免疫反应
7. Lymphoid Organs as a Major Reservoir for Human T-Cell Leukemia Virus Type 1 in Experimentally Infected Squirrel Monkeys (Saimiri sciureus): Provirus Expression, Persistence, and Humoral and Cellular Immune Responses [O] . Kazanji, Mirdad, Ureta-Vidal, Abel, Ozden, Simona, 2000

机译：淋巴器官作为实验性感染的松鼠猴（Saimiri sciureus）中人T细胞白血病病毒1型的主要储存库：原病毒表达，持久性以及体液和细胞免疫反应
8. Leukemias Associated with Human T-Cell Lymphotropic Virus Type I in a Non-Endemic Region. (Reannouncement with New Availability Information). [R] . Ratner, L., Poiesz, B. J. 1988

机译：白血病与非地方区域的人类T细胞淋巴细胞病毒I型相关。（重新公布新的可用性信息）。

Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis

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