Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil.

Johnson MR; Diasio RB

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Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil.

机译：在用5-氟尿嘧啶治疗后表现出毒性的患者中，二氢嘧啶脱氢酶（DPD）缺乏症的重要性。

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来源
《Advances in enzyme regulation》 |2001年第0期|共7页
作者
Johnson MR; Diasio RB;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Antimetabolites; Antineoplastic; Fluorouracil; Oxidoreductases; dihydrouracil dehydrogenase(NADP); 抗代谢药; 抗肿瘤; 氟尿嘧啶; 氧化还原酶类;

机译：Antimetabolites;Antineoplastic;Fluorouracil;Oxidoreductases;dihydrouracil dehydrogenase(NADP);抗代谢药;抗肿瘤;氟尿嘧啶;氧化还原酶类;

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1. Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil. [J] . Johnson MR, Diasio RB Advances in enzyme regulation . 2001,第0期

机译：在用5-氟尿嘧啶治疗后表现出毒性的患者中，二氢嘧啶脱氢酶（DPD）缺乏症的重要性。
2. Lethal 5-fluorouracil toxicity in a colorectal patient with severe dihydropyrimidine dehydrogenase (DPD) deficiency [J] . Dhelens Carole, Bonadona Agnes, Thomas Fabienne, International journal of colorectal disease. . 2016,第3期

机译：致致死的5-氟尿嘧啶毒性在具有严重二氢嘧啶脱氢酶（DPD）缺乏的结肠直肠患者中
3. Severe toxicity following capecitabine administration because of dihydropyrimidine deshydrogenase (DPD) deficiency [Toxicité sévère à la capécitabine liée à un déficit enzymatique en dihydropyrimidine déshydrogénase (DPD)] [J] . CoursierS., MarteletS., GuillermetA., Gastroenterologie clinique et biologique . 2010,第3期

机译：卡培他滨给药后由于二氢嘧啶脱氢酶（DPD）缺乏而引起严重毒性
4. Thymidine Phosphorylase (TP) and Dihydropyrimidine Dehydrogenase (DPD) in Colorectal Cancer: Gene Expressions Level vs. Protein Level [C] . J. Sobajima, T. Gonda, T. Oosawa, International Society of University Colon and Rectal Surgeons . 2006

机译：结直肠癌中胸苷磷酸化酶（TP）和二氢嘧啶脱氢酶（DPD）：基因表达水平与蛋白质水平
5. Development, validation, and use of a novel [2-carbon-13] uracil breath test to detect dihydropyrimidine dehydrogenase deficiency. [D] . Mattison, Lori K. 2006

机译：开发，验证和新型的[2-carbon-13]尿嘧啶呼气试验来检测二氢嘧啶脱氢酶缺乏症。
6. P-040Dihydropyrimidine Dehydrogenase (DPD) and Thymidylate Synthase (TYMS) Germline Pharmacogenomics Role in Predicting Fluoropyrimidines Toxicity in Patients with Gastrointestinal (GI) Malignancies [O] . M. Khushman, P. Hosein, D. Cameron, -1

机译：P-040二氢嘧啶脱氢酶（DPD）和胸苷酸合酶（TYMS）生殖遗传药理学在预测胃肠道（GI）恶性肿瘤患者的氟嘧啶毒性中的作用
7. FUSAFE individual patient data meta-analysis (MA) to assess the performance of dihydropyrimidine dehydrogenase (DPD) gene polymorphisms for predicting grade 4-5 fluoropyrimidine (FP) toxicity [O] . M.-C. Etienne-Grimaldi, N. Cozic, J.-C. Boyer, 2019

机译：Fusafe单独患者数据Meta分析（MA）以评估二氢嘧啶脱氢酶（DPD）基因多态性的性能预测4-5级氟嘧啶（FP）毒性

Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil.

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