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首页> 外文期刊>European journal of pain : >Behavioural, morphological and electrophysiological assessment of the effects of type 2 diabetes mellitus on large and small nerve fibres in Zucker diabetic fatty, Zucker lean and Wistar rats
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Behavioural, morphological and electrophysiological assessment of the effects of type 2 diabetes mellitus on large and small nerve fibres in Zucker diabetic fatty, Zucker lean and Wistar rats

机译：2型糖尿病患者对Zucker糖尿病脂肪，Zucker瘦和Wistar大鼠大小神经纤维作用的行为，形态学和电生理学评估

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Abstract Background Peripheral neuropathy is a common complication in type 2 diabetes mellitus (T2 DM ). The most common presentation is in the form of a distal axonal sensory‐motor polyneuropathy that involves large and small nerve fibres in variable proportion. Methods Zucker Diabetic Fatty ( ZDF ), Zucker Lean ( ZL ) and Wistar Han ( WH ) rats were used to assess the behavioural, morphological and electrophysiological effects that T2 DM have on peripheral large and small nerve fibres of 6‐ to 40‐week‐old rats. Results ZDF rats presented mechanical hypersensitivity that initially worsened in parallel to the progression of diabetes and eventually reverted at later stages of the disease. The reversal from hypersensitivity to hyposensitivity paralleled a reduction in the number of intraepithelial skin nerve terminals and in the nerve fibre lengths. However, no increased levels of degeneration of dorsal root ganglion neurons were observed. Nerve conduction studies showed a reduction in sensory and motor nerve conduction velocity ( CV ) in hyperglycaemic ZDF rats. Microneurography showed significant alterations in several parameters of activity‐dependent slowing ( ADS ) of mechano‐insensitive C‐nociceptors in ZDF rats. Surprisingly, some of these changes were also observed in ZL rats. Moreover, we found spontaneous activity in all three strains implying that C‐nociceptors become hyperexcitable and spontaneously active not only in ageing hyperglycaemic ZDF rats but also in age‐matched and apparently normoglycaemic ZL and WH rats fed with the same diet. Conclusions ZDF rats presented a diabetic neuropathy involving large and small nerve fibres; additionally, ZL and WH rats also showed early small abnormalities in C‐fibres, clearly detected by microneurography Significance This study provides a functional description of large and small nerve fibre function in a diabetic model that recapitulates many of the findings observed in patients suffering from type 2 diabetes mellitus.
机译：摘要背景外周神经病变是2型糖尿病（T2 DM）的常见并发症。最常见的呈现是远端轴突式感官电动机多肌病的形式，其涉及可变比例的大而小神经纤维。方法采用Zucker糖尿病脂肪（ZDF），Zucker瘦（ZL）和Wistar Han（WH）大鼠评估T2 DM对6至40周的外周大和小神经纤维的行为，形态和电生理学效应老鼠。结果ZDF大鼠呈现出机械超敏反应，最初与糖尿病的进展平行，最终恢复疾病的后期。从过敏到过敏性的逆转程度平行于上皮内皮神经末端和神经纤维长度的减少。然而，观察到背根神经节神经元的退变水平增加。神经传导研究表明，高血糖ZDF大鼠的感觉和运动神经传导速度（CV）降低。微调术在ZDF大鼠机械不敏感C-NOCICEPTORS的若干活动依赖性速度（ADS）的几个参数中显示出显着的改变。令人惊讶的是，在ZL大鼠中也观察到这些变化中的一些。此外，我们发现所有三种菌株中的自发性活性暗示C-Noicpopers不仅在老化高血糖ZDF大鼠中变得过度兴奋和自发活跃，而且在年龄匹配和明显的正常性ZL和喂食同期饮食的WH大鼠。结论ZDF大鼠呈现糖尿病神经病变，涉及大型神经纤维;另外，ZL和WH大鼠还显示出C纤维的早期小异常，通过微术意义清楚地检测该研究，本研究提供了在糖尿病模型中的大小神经纤维功能的功能描述，该模型概述了患有类型的患者中观察到的许多研究结果2糖尿病。

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  • 来源
    《European journal of pain :》 |2018年第8期|共16页
  • 作者

    Garcia‐Perez E.; Sch?nberger T.; Sumalla M.; Stierstorfer B.; Solà R.; Doods H.; Serra J.; Gorodetskaya N.;

  • 作者单位

    Neuroscience TechnologiesBarcelona Spain;

    Boehringer Ingelheim Pharma GmbH &

    Co. KGBiberach an der Riss Germany;

    Neuroscience TechnologiesBarcelona Spain;

    Boehringer Ingelheim Pharma GmbH &

    Co. KGBiberach an der Riss Germany;

    Neuroscience TechnologiesBarcelona Spain;

    Boehringer Ingelheim Pharma GmbH &

    Co. KGBiberach an der Riss Germany;

    Neuroscience TechnologiesBarcelona Spain;

    Boehringer Ingelheim Pharma GmbH &

    Co. KGBiberach an der Riss Germany;

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  • 正文语种 eng
  • 中图分类 诊断学;
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