Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene

Kato Sho; Motoyama Takayuki; Uramoto Masakazu; Nogawa Toshihiko; Kamakura Takashi; Osada Hiroyuki

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Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene

机译：循环霉素B诱导次级代谢产物生产及其具有自抗基因的1233A生物合成基因簇的鉴定

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We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK97-94. We identified the biosynthetic gene cluster for 1233A, an HMG-CoA synthase inhibitor. The biosynthetic gene cluster consisted of four genes, one of which was involved in conferring self-resistance to 1233A.

机译：我们发现，蛋白质合成抑制剂潮霉素B诱导丝酰胺，包括含氟胺，NG-391，Fusarubin，1233A和1233B的次级代谢物的产生。 RK97-94。我们鉴定了1233A的生物合成基因簇，是HMG-COA合酶抑制剂。生物合成基因簇由四个基因组成，其中一个基因涉及赋予1233A的自体抗性。

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《The Journal of Antibiotics: An International Journal》 |2020年第7期|共5页
作者
Kato Sho; Motoyama Takayuki; Uramoto Masakazu; Nogawa Toshihiko; Kamakura Takashi; Osada Hiroyuki;
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RIKEN CSRS Chem Biol Res Grp Wako Saitama Japan;

RIKEN CSRS Chem Biol Res Grp Wako Saitama Japan;

RIKEN CSRS Chem Biol Res Grp Wako Saitama Japan;

RIKEN CSRS Chem Biol Res Grp Wako Saitama Japan;

Tokyo Univ Sci Fac Sci &

Technol Dept Appl Biol Sci Noda Chiba Japan;

RIKEN CSRS Chem Biol Res Grp Wako Saitama Japan;

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正文语种 eng
中图分类药学;
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1. Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene [J] . Kato Sho, Motoyama Takayuki, Uramoto Masakazu, The Journal of Antibiotics: An International Journal . 2020,第7期

机译：循环霉素B诱导次级代谢产物生产及其具有自抗基因的1233A生物合成基因簇的鉴定
2. Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster [J] . Palaniappan N, Ayers S, Gupta S, Chemistry & biology . 2006,第7期

机译：通过鉴定和操纵生物合成基因簇在吸水链霉菌NRRL 2388中生产潮霉素A类似物
3. Impacts of environmental stress on growth, secondary metabolite biosynthetic gene clusters and metabolite production of xerotolerant/xerophilic fungi [J] . Medina Angel, Schmidt-Heydt Markus, Rodriguez Alicia, Current Genetics: Eukaryotes with Emphasis on Yeasts, Fungi, Mitochondria, Plastids . 2015,第3期

机译：环境胁迫对耐旱/嗜干真菌生长，次生代谢产物生物合成基因簇和代谢产物产生的影响
4. CONSTRUCTION OF A SECONDARY METABOLITE DEFICIENT PENICILLIUM CHRYSOGENUM STRAIN AS A GENERIC PRODUCTION HOST FOR SECONDARY METABOLITES [C] . Fabiola Polli, Annarita Viaggiano, Oleksander Salo, Enzyme engineering XXIV . 2017

机译：次生代谢缺陷型青霉青霉菌菌株的构建，作为次生代谢产物的一般生产宿主
5. Characterization of putative self-resistance genes in the biosynthetic gene cluster of hygromycin A from Streptomyces hygroscopicus NRRL 2388. [D] . Dhote, Vidya. 2009

机译：吸水链霉菌NRRL 2388的潮霉素A生物合成基因簇中推定的自我抗性基因的表征。
6. Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds [O] . Lynn M. Naughton, Stefano Romano, Fergal O’Gara, -1

机译：伪弧菌属中次级代谢产物基因簇的鉴定揭示了产生新型生物活性化合物的令人鼓舞的生物合成潜力。
7. Identification of secondary metabolite gene clusters in the Pseudovibrio genus reveals encouraging biosynthetic potential toward the production of novel bioactive compounds [O] . Naughton, Lynn M., Romano, Stefano, O'Gara, Fergal, 2017

机译：伪弧菌属次生代谢产物基因簇的鉴定揭示了令人鼓舞的生物合成潜力，可用于生产新型生物活性化合物

Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene

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