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首页> 外文期刊>Alcohol >Intermittent access to beer promotes binge-like drinking in adolescent but not adult Wistar rats.
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Intermittent access to beer promotes binge-like drinking in adolescent but not adult Wistar rats.

机译：间歇性获取啤酒会促进青春期的狂饮般饮酒，但不能促进成年Wistar大鼠的饮酒。

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Teenagers are more likely than adults to engage in binge drinking and could be more vulnerable to long-term brain changes following alcohol abuse. We investigated the possibility of excessive adolescent drinking in a rodent model in which beer (4.44% ethanol vol/vol) is presented to adult and adolescent male Wistar rats. Experiment 1 tracked ad libitum beer and water consumption in group-housed rats from postnatal day (PND) 28-96. Rats consumed an average of 7.8 g/kg/day of ethanol during adolescence (PND 34-55) and this gradually declined to a lower level of intake in adulthood (PND 56-93) of 3.9 g/kg/day. In Experiment 2, beer was made available to both adolescent (PND 29+) and adult (PND 57+) rats for 2h each day in a custom-built "lickometer" apparatus over 75 days. Access to beer was provided either 1 day out of every 3 ("intermittent" groups) or every day ("daily" groups). Relative to body weight, adolescent rats consumed more beer than adult rats in these limited access sessions. Adolescents with intermittent access consumed more than adolescents with daily access, a "binge"-like effect that was not observed in adult groups and that disappeared in adulthood. After 3 months of daily or intermittent alcohol consumption, the preference for beer versus sucrose was assessed. Rats previously kept under an intermittent schedule displayed a higher preference for beer relative to 3% sucrose, but only when testing occurred after 2 days of abstinence. In Experiment 3, adolescent (PND 30-37) and adult (PND 58-65) rats were given 20-min access to beer and their blood alcohol concentrations (BACs) were assessed. Adolescent groups consumed more alcohol than adults and showed higher BACS that were typical of human binge intake was similar in both age groups. Together these results show that the intermittent presentation of alcohol itself appears to have subtle long-lasting effects on the motivation to consume alcohol. The findings support the use of beer solutions in modeling binge-like patterns of human alcohol consumption in adolescent rats.
机译：青少年比成年人更容易暴饮暴食，并且更容易因酗酒而长期脑部改变。我们研究了在成年和青春期雄性Wistar大鼠使用啤酒（4.44％乙醇体积/体积）的啮齿动物模型中青少年过量饮酒的可能性。实验1追踪了出生后28-96天（PND）的成群饲养的大鼠的随意啤酒和水消耗量。在青春期，大鼠平均每天摄入7.8 g / kg /天的乙醇（PND 34-55），成年后逐渐降低至3.9 g / kg /天的较低摄入量（PND 56-93）。在实验2中，在定制的“测力计”仪器中，经过75天，每天向青少年（PND 29+）和成年（PND 57+）大鼠提供啤酒2小时。每3天（“间歇”组）中有1天或每天（“每日”组）中有一天可以喝啤酒。相对于体重，在这些有限的访问时段中，青春期大鼠比成年大鼠消耗更多的啤酒。间歇性访问的青少年比日常访问的青少年消费更多，这是一种“暴跳”效应，在成年群体中没有观察到，并且在成年后消失了。每天或间断饮酒3个月后，评估了啤酒与蔗糖的偏爱。相对于3％的蔗糖，以前以间歇性时间表进行治疗的大鼠对啤酒表现出更高的偏爱，但仅在禁欲2天后进行测试时才显示。在实验3中，给青春期（PND 30-37）和成年（PND 58-65）大鼠使用20分钟的啤酒，并评估其血液酒精浓度（BAC）。青少年组的酒精消费量比成人多，并且显示出较高的BACS，这是两个年龄段的人暴饮暴食的典型特征。这些结果加在一起表明，酒精本身的间歇性呈现似乎对饮酒的动机具有微妙的长期影响。这些发现支持啤酒溶液用于模拟青春期大鼠暴饮暴食模式。

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