• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Antimicrobial activity of immobilized lactoferrin and lactoferricin
【24h】

Antimicrobial activity of immobilized lactoferrin and lactoferricin

机译：固定的乳铁蛋白和乳铁蛋白的抗微生物活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Lactoferrin and lactoferricin were immobilized on glass surfaces via two linkers, 4‐azidobenzoic acid (ABA) or 4‐fluoro‐3‐nitrophenyl azide (FNA). The resulting surfaces were characterized by X‐ray photoelectron spectroscopy (XPS) and contact angle measurements. The antimicrobial activity of the surfaces was determined using Pseudomonas aeruginosa and Staphylococcus aureus strains by fluorescence microscopy. Lactoferrin and lactoferricin immobilization was confirmed by XPS showing significant increases ( p ??0.05) in nitrogen on the glass surface. The immobilization of both proteins slightly increased the overall hydrophobicity of the glass. Both lactoferrin and lactoferricin immobilized on glass significantly ( p ??0.05) reduced the numbers of viable bacterial cells adherent to the glass. For P. aeruginosa , the immobilized proteins consistently increased the percentage of dead cells compared to the total cells adherent to the glass surfaces ( p ??0.03). Lactoferrin and lactoferricin were successfully immobilized on glass surfaces and showed promising antimicrobial activity against pathogenic bacteria. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2612–2617, 2017.
机译：摘要乳铁蛋白和乳叶苷通过两个接头，4-吖啶苯甲酸（ABA）或4-氟-3-硝基苯基叠氮化物（FNA）固定在玻璃表面上。由X射线光电子能谱（XPS）和接触角测量表征得到的表面。通过荧光显微镜使用假单胞菌铜绿假单胞菌和金黄色葡萄球菌菌株测定表面的抗微生物活性。通过XPS确认乳蛋白和乳叶素固定化，显示在玻璃表面上的氮气中的显着增加（p≤≤0.05）。两种蛋白质的固定化略微增加了玻璃的整体疏水性。乳铁蛋白和乳叶苷均显着固定在玻璃上（p≤≤0.05）减少粘附在玻璃上的活细菌细胞的数量。对于铜绿假单胞菌，与粘附在玻璃表面的总细胞相比，固定化蛋白质始终增加死细胞的百分比（p≤≤0.03）。 Lactoferrin和Lactoferricin成功地固定在玻璃表面上，并显示出对致病细菌的有前途的抗微生物活性。还2016 Wiley期刊，Inc .J生物保解员B：Appl Biomater，105B：2612-2617，2017。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号