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首页> 外文期刊>Journal of mass spectrometry: JMS >Hydralazine derivative of aldehyde: A new type of [M - H](+) ion formed in electrospray ionization mass spectrometry
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Hydralazine derivative of aldehyde: A new type of [M - H](+) ion formed in electrospray ionization mass spectrometry

机译：醛的氢吡啶衍生物：在电喷雾电离质谱中形成的一种新型的[M-H]（+）离子

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摘要

Hydralazine has been widely employed in the development of drugs, derivatization reagents, and ligands. In the present work, we reported a new type of dehydrogenated ion [M - H](+) that was produced from the hydralazine derivative of hexanal in electrospray ionization mass spectrometry (ESI-MS). The formation of [M - H](+) ions in the ESI-MS was found to be independent on the mobile phase composition of the liquid chromatography and ESI source parameters. A series of hydralazine derivatives of aldehyde were investigated to confirm this phenomenon. The results showed that hydralazine derivatives of aldehydes that contained an sp(3) hybridization carbon with a hydrogen at the alpha-position of aldehydes could form the unexpected [M - H](+) ions, whereas hydralazine derivative of acetone could only generate [M + H](+) ion in the ESI-MS. We proposed the possible formation mechanism of [M - H](+) ion for the hydralazine derivatives of aldehydes: the [M - H](+) ion was possibly formed by the loss a hydrogen molecule (H-2) from the protonated ion [M + H](+). The results obtained from density functional theory (DFT) calculations supported this proposed formation mechanism of [M - H](+) ion.
机译：碘嗪已广泛用于制造药物，衍生化试剂和配体。在本作工作中，我们报道了一种新型的脱氢离子[M-H]（+），其由电喷雾电离质谱（ESI-MS）的普通酸酐衍生物产生。发现ESI-MS中的[M-H]（+）离子的形成是独立于液相色谱和ESI源参数的流动相组合物。研究了一系列醛的卤吡嗪衍生物，以确认这种现象。结果表明，在醛的α-位置含有氢气的醛的卤代嗪衍生物可以形成意外的[M-H]（+）离子，而丙酮的碘嗪衍生物只能产生[在ESI-MS中M + H]（+）离子。我们提出了[M - H]（+）离子的可能形成机制，用于醛的卤代嗪衍生物：[M-H]（+）离子可能由损失来自质子化的氢分子（H-2）形成离子[m + h]（+）。从密度泛函理论（DFT）计算中获得的结果支持了[M - H]（+）离子的该构建机制。

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