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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Impact of Covert Lacunar Infarcts and White Matter Hyperintensities on Cognitive and Motor Outcomes After Stroke
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The Impact of Covert Lacunar Infarcts and White Matter Hyperintensities on Cognitive and Motor Outcomes After Stroke

机译：隐蔽曲线图和白质超收缩对中风后认知和电机结果的影响

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Background and Aims: In addition to overt stroke lesions, co-occurring covert lesions, including white matter hyperintensities (WMH) and covert lacunar infarcts (CLI), contribute to poststroke outcome. The purpose of this study was to examine the relationship between covert lesions, and motor and cognitive outcomes in individuals with chronic stroke. Methods: Volumetric quantification of clinically overt strokes, covert lesions (periventricular and deep: pWMH, dWMH, pCLI, dCLI), ventricular and sulcal CSF (vCSF, sCSF), and normal appearing white (NAWM) and gray matter (NAGM) was performed using structural magnetic resonance imaging. We assessed motor impairment and function, and global cognition, memory, and other cognitive domains. When correlation analysis identified more than one MR parameter relating to stroke outcomes, we used regression modeling to identify which factor had the strongest impact. Results: Neuropsychological and brain imaging data were collected from 30 participants at least 6 months following a clinically diagnosed stroke. Memory performance related to vCSF (r = -0.52, P = .004). The strongest predictor of nonmemory domains was pCLI (r(2) = 0.28, P = .004). Motor impairment and function were most strongly predicted by the volume of stroke and NAWM (r(2) = 0.36; P = .001), and dWMH (r(2) = 0.39; P = .001) respectively. Conclusions: Covert lesion type and location have important consequences for post-stroke cognitive and motor outcome. Limiting the progression of covert lesions in aging populations may enhance the degree of recovery post-stroke.
机译：背景和目的：除了公开的中风病变外，共同发生的封面病变，包括白质高萎缩性（WMH）和覆盖物格鲁纳梗塞（CLI），有助于出现逾速期。本研究的目的是审查具有慢性中风的个体的隐蔽病变和运动和认知结果之间的关系。方法：临床上公开笔触的体积定量，覆盖病变（颈部和深：PWMH，DWMH，PWCLI，DCLI），心室和硫，CSF（VCSF，SCSF）和正常出现的白色（NAWM）和灰质（NAGM）进行正常出现的白色（NAGM）和正常出现的白色（NAGM）使用结构磁共振成像。我们评估了电机损伤和功能，以及全球认知，记忆和其他认知域。当相关性分析确定与笔划结果相关的一个以上的MR参数时，我们使用回归建模来确定哪个因素具有最强的影响。结果：在临床诊断的中风后至少6个月收集神经心理学和脑成像数据。与VCSF相关的内存性能（r = -0.52，p = .004）。非媒体域的最强预测因子是PCLI（R（2）= 0.28，p = .004）。电动机损伤和功能最强烈地通过中风和NAWM（R（2）= 0.36; p = .001），DWMH（R（2）= 0.39; p = .001）预测。结论：隐蔽病变类型和位置对冲程后认知和电机结果具有重要影响。限制老龄化群体中隐蔽病变的进展可能会提高中风后恢复程度。

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