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首页> 外文期刊>Journal of vector borne diseases >Synchronic macrophage response and Plasmodium falciparum malaria.
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Synchronic macrophage response and Plasmodium falciparum malaria.

机译：同步巨噬细胞反应和疟原虫疟疾。

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摘要

Human Chitotriosidase (CHIT), produced by activated macrophage, is a member of the chitinase family, a group of enzymes with the capability to hydrolyze chitin. Recently plasma CHIT activity was found elevated in children with acute P. falciparum malaria compared with healthy African children, as a consequence of macrophage activation due to the presence of parasites. In this study we recruited at the local Centre Medical Saint Camille (CMSC) of Ouagadougou, the capital of Burkina Faso, 62 African children (30 males and 32 females, aged 2-140 months; median 16.5 months), affected by acute P. falciparum malaria, bora and living in Burkina Faso. Control subjects included 140 healthy African children (79 males and 61 females) with age ranging from 10 to 100 months (median 22 months) at evaluation time. They did not show signs of acute infectious disease and their blood smears for P. falciparum were negative. This study was approved by the local Ethical Committees of CMSC. Parents of the participating children in the study were orally informed of the scope of this research. For plasma CHIT assay, 3 ml of EDTA-blood was centrifuged and plasma samples were stored at -40deg C untildetermination by fluorimetric method at the Centre for Metabolic Diseases-University of Catania, Italy.
机译：通过活化的巨噬细胞产生的人际千核苷酸酶（CHIT）是逐蛋白酶家族的成员，一组酶具有水解甲壳素的能力。最近，由于寄生虫的存在，急性P.Malciparum疟疾的儿童发现急性P. falciparum疟疾的儿童升高。在这项研究中，我们在布基纳法索的首都瓦加杜古的当地中心医疗圣马克（CMSC）招募了62名非洲儿童（30名男性和32名女性，2-140个月;中位数16.5个月），受急性P.疟疾疟疾，博拉和生活在布基纳法索。控制受试者包括140名健康的非洲儿童（79名男性和61名女性），年龄在评估时间10至100个月（中位数22个月）。他们没有表现出急性传染病的迹象，并且他们的血液涂片对于p. falciparum是阴性的。本研究经CMSC的当地道德委员会批准。参与儿童的父母在研究中被展开了这项研究的范围。对于等离子体Chit测定，将3mL的EDTA-血液离心，并在意大利代谢疾病大学的荧光法将血浆样品在-40deg C中储存。

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