Overview of biological mechanisms of human carcinogens

Birkett Nicholas; Al-Zoughool Mustafa; Bird Michael; Baan Robert A.; Zielinski Jan; Krewski Daniel

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Overview of biological mechanisms of human carcinogens

机译：人致癌物体生物机制概述

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This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.

机译：本综述总结了通过IARC专着的106份确定为人类癌症的109组人致癌物质的致癌机制。国际癌症研究机构（IARC）评估了涉嫌诱导人类癌症的药剂的人类，实验和机械证据，使用既定的证据方法。专着提供有关所有致癌物质的详细机制信息。致癌物理与致癌物质（例如，发射α颗粒的药物）的致癌物质组合成审查。主要基于IARC专着的信息，提出了86个致癌或致癌基因组的机械谱的叙述性概要，介绍了IARC专着的信息，补充了非系统性审查。大多数致癌物质包括遗传毒性机制。

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《Journal of toxicology and environmental health, Part B. Critical reviews》 |2019年第8期|共72页
作者
Birkett Nicholas; Al-Zoughool Mustafa; Bird Michael; Baan Robert A.; Zielinski Jan; Krewski Daniel;
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作者单位

Univ Ottawa Sch Epidemiol &

Publ Hlth Ottawa ON Canada;

King Saud bin Abdulaziz Univ Hlth Sci Dept Community &

Environm Hlth Riyadh Saudi Arabia;

Univ Ottawa Fac Med McLaughlin Ctr Populat Hlth Risk Assessment Ottawa ON Canada;

Int Agcy Res Canc Lyon France;

Univ Ottawa Sch Epidemiol &

Publ Hlth Ottawa ON Canada;

Univ Ottawa Sch Epidemiol &

Publ Hlth Ottawa ON Canada;

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原文格式 PDF
正文语种 eng
中图分类环境卫生、环境医学;
关键词
Human carcinogens; key characteristics; sources of evidence; carcinogenesis; mechanisms of action;

机译：人致癌;关键特征;证据来源;致癌物;行动机制;

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Overview of biological mechanisms of human carcinogens

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