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首页> 外文期刊>Journal of women’s health >Prolonged Amenorrhea and Resumption of Menses in Women with HIV
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Prolonged Amenorrhea and Resumption of Menses in Women with HIV

机译：延长闭经和艾滋病毒妇女的月经恢复

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Objective: To compare etiologies of prolonged amenorrhea in a cohort of HIV-infected women with a cohort of similar uninfected at-risk women. Materials and Methods: Women from the Women's Interagency HIV Study were seen every 6 months, and completed surveys including questions about their menstruation. Those who reported no vaginal bleeding for at least 1 year (prolonged amenorrhea) with subsequent resumption of bleeding were compared with women in whom bleeding had stopped permanently (menopause). Characteristics associated with reversible prolonged amenorrhea were ascertained. Results: Of 828 women with prolonged amenorrhea, 37.6% had reversible amenorrhea and 62.4% never resumed menses. HIV-seropositive women with prolonged amenorrhea were significantly younger at cessation of menses than HIV-negative women (p0.0001). Of those with reversible prolonged amenorrhea, approximately half were taking medications associated with amenorrhea, including 95 (30.6%) hormonal contraception, 80 (25.7%) opiates/stimulants, 16 (5.1%) psychotropic medications, and 6 (1.9%) chemotherapy. HIV-seropositive women were less likely to have medications as a cause of amenorrhea than seronegative women (p=0.02). In multivariable analysis, women with reversible prolonged amenorrhea of unknown etiology were younger (p0.0001), more often obese (p=0.03), and less educated (p=0.01) than those with permanent amenorrhea. Among HIV-seropositive women, markers of severe immunosuppression were not associated with prolonged amenorrhea. Conclusion: Women with HIV infection have unexplained prolonged amenorrhea more often than at-risk seronegative women. This is especially common among obese, less-educated women. Prolonged amenorrhea in the HIV-seropositive women should be evaluated and not be presumed to be to the result of menopause.
机译：目的：比较患有艾滋病毒感染妇女队列的长期闭经的病因，其中包含类似的未感染的危险妇女的群体。材料和方法：来自妇女间的患者艾滋病毒研究的妇女每6个月都看到了每6个月，并完成了关于他们月经的问题的调查。与随后恢复出血的妇女没有永久停止（更年期），那些报告至少1年的阴道出血（延长的闭经）。确定了与可逆延长闭经相关的特征。结果：828名患有近期闭经的女性，37.6％具有可逆的闭合症，62.4％从未恢复过量。患有延长的闭经的艾滋病毒血液阳性女性在月经的停止时比HIV阴性女性（P <0.0001）持续下降。在可逆延长的闭经的那些中，大约一半正在服用与闭经相关的药物，包括95（30.6％）激素避孕，80（25.7％）阿片类/兴奋剂，16（5.1％）精神药物，6（1.9％）化疗。艾滋病毒血清阳性女性的可能性不太可能与血管药物女性的常牙原因（p = 0.02）。在多变量分析中，具有可逆性未知病因的可逆延长闭经的妇女更年轻（P <0.0001），肥胖常常肥胖（P = 0.03），并且受过常见闭经的那些受过教育（P = 0.01）。在艾滋病毒血清阳性女性中，严重免疫抑制的标志物与延长的闭经无关。结论：艾滋病毒感染的妇女患有不明原因的延长的闭经，往往是风险的血液血清妇女。这在肥胖，受教育较少的女性中特别普遍。应评估艾滋病毒血清阳性妇女的延长的闭经，并被认为是更年期的结果。

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