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首页> 外文期刊>Current Analytical Chemistry >Determination of Trace Inorganic Germanium in bis-beta-Carboxyethyl-germanium Sesquioxide by Headspace Solid-Phase Microextraction and Gas Chromatography - Mass Spectrometry
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Determination of Trace Inorganic Germanium in bis-beta-Carboxyethyl-germanium Sesquioxide by Headspace Solid-Phase Microextraction and Gas Chromatography - Mass Spectrometry

机译：顶空固相微萃取-气相色谱-质谱法测定双-β-羧乙基-锗倍半氧化物中的痕量无机锗

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摘要

Organic germanium compounds, such as bis-beta-carboxyethylgermanium sesquioxide ("Ge-132"), have attained widespread distribution - particularly in self-medication - and are applied as tonics due to their presumed anticancer activities. In general, the toxicity of this particular organo-germanium compound is low. In contrast to this, acute and chronic toxic effects of inorganic germanium dioxide (GeO_2) have been demonstrated. In this paper, chloride-generation headspace solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) is proposed as a technique for the determination of trace amounts of GeO_2 in Ge-132. This method takes advantage of the fact that Ge-132 is not able to generate volatile species upon reaction with conc. HCl. The conditions for the generation of germanium chloride (GeCl_4), such as SPME fibre selection, extraction time and HCl concentration were investigated. The detection limit was established at 0.28 μg/ml (as Ge). Thus, this approach provides a novel, simple and fast platform for the determination of inorganic Ge in organogermanium formulations.
机译：有机锗化合物，例如双-β-羧乙基锗倍半氧化物（“ Ge-132”），已获得广泛的分布-特别是在自我药物治疗中-由于其假定的抗癌活性而被用作补品。通常，该特定的有机锗化合物的毒性低。与此相反，已经证明了无机二氧化锗（GeO_2）的急性和慢性毒性作用。本文提出了氯代顶空固相微萃取（SPME）结合气相色谱-质谱（GC-MS）作为测定Ge-132中痕量GeO_2的技术。该方法利用了以下事实：Ge-132在与浓盐酸反应后不能生成挥发性物质。盐酸。研究了生成氯化锗（GeCl_4）的条件，例如SPME纤维的选择，提取时间和HCl浓度。检出限设定为0.28μg/ ml（以Ge计）。因此，该方法为测定有机锗配方中的无机锗提供了新颖，简单，快速的平台。

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