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首页> 外文期刊>American Journal of Physiology >Effects of intraduodenal coadministration of lauric acid and leucine on gut motility, plasma cholecystokinin, and energy intake in healthy men
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Effects of intraduodenal coadministration of lauric acid and leucine on gut motility, plasma cholecystokinin, and energy intake in healthy men

机译：桂酸和亮氨酸内胆碱同学对健康男性肠蠕动，血浆胆囊素和能量摄入量的影响

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摘要

The fatty acid, lauric acid (C12), and the amino acid, leucine (Leu) stimulate gut hormones, including CCK, associated with suppression of energy intake. In our recent study, intraduodenal infusion of a combination of C12 and L-trypto-phan, at loads that individually did not affect energy intake, reduced energy intake substantially, associated with much greater stimulation of CCK. We have now investigated whether combined administration of C12 and Leu would enhance the intake-suppressant effects of each nutrient, when given at loads that each suppress energy intake individually. Sixteen healthy, lean males (age: 23 ± 2 yr) received, in randomized, double-blind fashion, 90-min intraduodenal infusions of control (saline), C12 (0.4 kcal/min), Leu (0.45 kcal/min), or Cl 2+Leu (0.85 kcal/min). Antropyloroduodenal pressures were measured continuously and plasma CCK at 15-min intervals, and energy intake from a standardized buffet-meal, consumed immediately postinfusion, was quantified. All nutrient infusions stimulated plasma CCK compared with control (P < 0.05). Moreover, C12 and C12+Leu stimulated CCK compared with Leu (P < 0.05) (mean concentration, pmol/L; control: 2.3 ± 0.3, C12: 3.8 ± 0.3, Leu: 2.7 ± 0.3, and C12+Leu: 4.0 ± 0.4). C12+Leu, but not C12 or Leu, stimulated pyloric pressures (P < 0.05). Cl 2+Leu and C12 reduced energy intake (P < 0.05), and there was a trend for Leu to reduce (P = 0.06) energy intake compared with control, with no differences between the three nutrient treatments (kcal; control: 1398 ± 84, C12: 1226 ± 80, Leu: 1260 ± 92, and C12+Leu: 1208 ± 83). In conclusion, combination of C12 and Leu, at the loads given, did not reduce energy intake beyond their individual effects, possibly because maximal effects had been evoked.
机译：脂肪酸，月桂酸（C12）和氨基酸，亮氨酸（Leu）刺激肠道激素，包括CCK，与抑制能量摄入相关。在我们最近的研究中，C12和L-TOTEPTO-PHAN的组合的颅内排卵，在单独地不影响能量摄取，减少能量摄入量大，与CCK的更大刺激相关。我们现在研究了C12和Leu的组合施用是否会增强每种营养素的进气抑制作用，当时每个抑制每种抑制能量摄入量。 16岁健康，瘦男性（年龄：23​​±2 Yr），在随机，双盲时尚，90分钟内肺结核输注（盐水），C12（0.4千卡/分钟），雷乌（0.45千卡/分钟），或Cl 2 + leu（0.85千卡/分钟）。用15分钟的间隔连续测量环氧丙基杂菌细胞压力，并定量从标准化自饮餐中消耗的标准化自饮食的能量摄入量。所有营养输注刺激血浆CCK与对照相比（P <0.05）。此外，C12和C12 + Leu刺激CCK与Leu（P <0.05）相比（平均浓度，PMOL / L;控制：2.3±0.3，C12：3.8±0.3，LEU：2.7±0.3，和C12 + Leu：4.0± 0.4）。 C12 + Leu，但不是C12或Leu，刺激幽门压力（P <0.05）。 C10 + leu和C12降低能量摄入量（P <0.05），leu有趋势减少（p = 0.06）能量摄入与对照相比，三种营养处理之间没有差异（kcal;控制：1398± 84，C12：1226±80，Leu：1260±92和C12 + Leu：1208±83）。总之，C12和Leu的组合，在给出的负载下，没有将能量摄入量降低到其个体效果之外，可能是因为最大效应被唤起。

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