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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Diversity of Mosaic pbp2x Families in Penicillin-Resistant Streptococcus pneumoniae from Iran and Romania
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Diversity of Mosaic pbp2x Families in Penicillin-Resistant Streptococcus pneumoniae from Iran and Romania

机译：来自伊朗和罗马尼亚的青霉素抗性链球菌肺炎链球菌肺炎链球菌的多样性

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摘要

Penicillin-resistant Streptococcus pneumoniae strains are found at high rates in Romania and Iran. The mosaic structure of PBP2x was investigated in 9 strains from Iran and in 15 strains from Romania to understand their evolutionary history. Mutations potentially important for beta-lactam resistance were identified by comparison of the PBP2x sequences with the sequence of the related PBP2x of reference penicillin-sensitive S. mitis strains. Two main PBP2x mosaic gene families were recognized. Eight Iranian strains expressed PBP2x variants in group 1, which had a mosaic block highly related to PBP2x of the Spain(23F)-1 clone, which is widespread among international penicillin-resistant S. pneumoniae clones. A second unique PBP2x group was observed in Romanian strains; furthermore, three PBP2x single mosaic variants were found. Sequence blocks of penicillin-sensitive strain S. mitis 658 were common among PBP2x variants from strains from both countries. Each PBP2x group contained specific signature mutations within the transpeptidase domain, documenting the existence of distinct mutational pathways for the development of penicillin resistance.
机译：青霉素抗性链球菌肺炎群菌株在罗马尼亚和伊朗的高利率下被发现。 PBP2x的马赛克结构在9次来自伊朗的9株中，从罗马尼亚的15个菌株中得到了解他们的进化历史。通过比较PBP2X序列与参考青霉素敏感的S.脑菌菌株的相关PBP2X序列的序列，鉴定了对β-内酰胺抗性的突变可能重要的突变。认识到两个主要的PBP2x马赛克基因系列。八个伊朗菌株在第1组中表达了PBP2x变体，其与西班牙（23f）-1克隆的PBP2x具有高度相关的马赛克块，这在国际青霉素抗性S.肺炎克隆中普及。在罗马尼亚菌株中观察到第二个独特的PBP2X组;此外，发现了三种PBP2X单一马赛克变体。青霉素敏感性菌株S.脑膜炎菌菌菌菌菌菌的序列块是来自两国菌株的PBP2x变体中常见。每个PBP2X组含有特异性肽酶结构域内的特异性签名突变，记录了对青霉素抗性的发展不同的突变途径。

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